Ciracle Tablets 250 mg (Clarithromycin)

Adult dose

Adults: The usual dose is 250 mg (potency) of clarithromycin per dose twice daily. For severe infections, administer 500 mg (potency) per dose twice daily. The usual duration of treatment is 7～14 days. In patients with renal failure and creatinine clearance of 30 mL/min or less, reduce the dose by half: administer 250 mg (potency) once daily, or, for severe infections, 250 mg (potency) per dose twice daily. Do not administer for more than 14 days in these patients. Mycobacterial infections: Administer 500 mg (potency) of this medicine per dose twice daily. In this case, it must be coadministered with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcer: Administer 500 mg (potency) of this medicine 3 times daily with omeprazole 40 mg once daily for 14 days, followed by omeprazole 40 mg once daily for 14 consecutive days. That is, administer clarithromycin 500 mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40 mg once daily for 28 days (days 1～28).

Child dose

Children 12 years and older: Same as adults. For children under 12 years, use clarithromycin dry syrup.

This medication should not be used in specific patients. Patients allergic to the components of this medication or similar antibiotics should not take it. Additionally, patients taking medications that may affect heart rhythm or those with severe liver or kidney disease should avoid this medication. Pregnant or breastfeeding women should not take it. Caution is also required for patients with central nervous system infections or those taking certain medications. This medication should be used with caution in patients with impaired liver or kidney function, heart disease, and the elderly. Care is needed when taken alongside other antibiotics, as cross-resistance or drug interactions may occur. Caution is also required for those with allergies to the medication. This medication rarely causes serious allergic reactions, skin rashes, gastrointestinal issues, liver function abnormalities, kidney function decline, or central nervous system adverse reactions. If any of these symptoms appear, discontinue use immediately and consult a healthcare professional. During antibiotic use, it is important to take the medication only for the necessary duration to prevent the emergence of resistant bacteria. If symptoms like diarrhea or abdominal pain persist during use, inform a healthcare professional. This medication may interact with other drugs, so be sure to inform your healthcare provider about any medications you are taking. Caution is especially important when taken with heart-related medications, anticoagulants, certain sedatives, and hypoglycemic agents. Use of this medication during pregnancy or breastfeeding is not recommended, and if unavoidable, consult a specialist. A careful assessment is also necessary for children and the elderly before administration. In case of overdose, gastrointestinal disorders or central nervous system adverse symptoms may occur, so visit a hospital immediately for appropriate treatment.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, urticaria, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal erosion, epigastric pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, loss of appetite, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, abdominal pain, frequent diarrhea, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltrate, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis exacerbation, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, hepatic dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, loss of appetite, jaundice, dark urine, pruritis, abdominal tenderness, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, elevated CPK, increased myoglobin in blood, increased myoglobin in urine, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste disturbances, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbances, tinnitus, auditory impairment, hypoglycemia, tinnitus, hearing loss, vomiting, nausea, abdominal pain, purpuric rash, acute pancreatitis, increased amylase, elevated AST, elevated ALT, elevated BUN, thrombocytopenia, leukopenia, eosinophilia, thrombocytosis, agranulocytosis, anaphylactic reaction, angioedema, loss of appetite, hypoglycemia, insomnia, anxiety, loudness, psychotic disorder, confusion state, depersonalization, depression, disorientation, hallucinations, abnormal dreams, mania, dysgeusia, headache, loss of consciousness, movement disorders, non-vertiginous dizziness, drowsiness, tremors, convulsions, loss of taste, abnormal olfaction, loss of smell, vertiginous dizziness, hearing impairment, hearing loss, cardiac arrest, atrial fibrillation, QT interval prolongation on ECG, ectopic beats, palpitations, vasodilation, bleeding, asthma, epistaxis, pulmonary embolism, diarrhea, vomiting, dyspepsia, nausea, abdominal pain, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, stomatitis, glossitis, abdominal distention, constipation, thirst, belching, bloating, acute pancreatitis, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyltransferase, liver failure, hepatocellular jaundice, rash, hyperhidrosis, vesicular dermatitis, itching, urticaria, papular rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, acne, Henoch-Schonlein purpura, acute generalized pustular psoriasis, muscle cramps, musculoskeletal stiffness, myalgia, rhabdomyolysis, myopathy, elevated blood creatinine, elevated blood urea, renal failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, malaise, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated blood alkaline phosphatase, elevated blood lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, urine color abnormalities, changes in mental status, compulsive behavior, hypokalemia, hypoxemia

This medication should be stored in a tightly closed container that can block light, and it is best to keep it at room temperature between 1 to 30 degrees Celsius. Proper storage maintains the drug's efficacy and safety.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle