Mepril Table (Glimepiride)

Adult dose

Adjusted individually for each patient. Swallow without chewing with more than 1/2 cup of water. This medication is taken orally once a day. It should be taken before breakfast or just before the first meal. Start dosing at 1 mg of glimepiride once daily. If necessary, the dose can be increased by 1 mg at intervals of 1-2 weeks. Generally, additional effects are minimal when doses over 4 mg are administered, but some may show better metabolic control with increases up to 6 mg (or 8 mg). If a dose of 4 mg is ineffective, switching to insulin therapy should be considered, otherwise combination therapy with insulin or other oral diabetes medications should be considered.

This medication is not to be used in patients with insulin-dependent diabetes or those in diabetic ketoacidosis or coma. Patients with allergies to this drug, its components, or sulfonylurea drugs should not receive it. For patients with severe liver or kidney dysfunction, it is recommended to switch to insulin therapy instead of using this drug. Women who are pregnant or potentially pregnant and those who are breastfeeding should not take this medication. Patients with severe infections, those who are undergoing surgery, or those with severe trauma should be treated with insulin and need to exercise caution during gastrointestinal disturbances such as diarrhea or vomiting due to the risk of hypoglycemia. Additionally, this drug contains lactose, so patients with lactose intolerance or specific genetic metabolic disorders should not take it. During the initial week of treatment, the risk of hypoglycemia is high, and close monitoring is particularly necessary for the elderly, malnourished patients, those with irregular meals, and frequent alcohol consumers. Patients with weak kidney or liver function, those who have overdosed, and those with thyroid or adrenal dysfunction may also have an increased risk of hypoglycemia. When taking this medication with other drugs, it is essential to inform your doctor or pharmacist, as it may affect blood sugar control. The most common side effect while taking this medication is hypoglycemia, manifesting as headaches, severe hunger, nausea, fatigue, confusion, drowsiness, and, in severe cases, coma. If symptoms of hypoglycemia occur, sugar should be consumed immediately, and in severe cases, emergency treatment may be necessary. During initial dosing, temporary blurred vision or gastrointestinal symptoms (nausea, vomiting, abdominal pain, etc.) may occur. Abnormal liver function, blood disorders, and allergic reactions can also occur rarely, so immediate reporting to healthcare professionals is essential if unusual symptoms arise. When taking this medication, it should be taken regularly in conjunction with dietary and exercise therapies, and patients should always carry sugar to prevent hypoglycemia. In stressful situations, during surgery, or during infections, blood sugar control can become difficult, so consultation with healthcare professionals may lead to a switch to insulin therapy. Pregnant or breastfeeding women should not take this medication due to the potential effects on the fetus or newborn; insulin therapy should be considered if necessary. In case of an overdose, severe hypoglycemia may occur, requiring immediate emergency care, which may involve inducing vomiting, gastric lavage, or glucose injections. The safety and efficacy of this medication have not been established in children, and elderly patients may require dosage adjustments due to declining kidney function.

Serious side effects

• Hives
• Severe swelling (edema)
• Chest tightness
• Difficulty breathing
• Cold sweat
• Pallor
• → Severe allergic reactions
• Severe rash along with high fever
• Blisters
• Skin peeling

Mild side effects

• Headaches
• severe hunger
• nausea
• vomiting
• fatigue
• sleepiness
• sleep disorders
• anxiety
• aggression
• decreased concentration

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. The storage temperature should be maintained at room temperature between 1°C and 30°C. This ensures the medication's efficacy is safely preserved.

Appearance

Green oblong tablet

Package unit

30 tablets/bottle, 100 tablets/bottle