Neomaril Tablet 2 mg (Glimepiride)

Adult dose

Adjust individually for each patient. This medication is taken orally once daily and should be swallowed whole with more than 1/2 cup of water. It should be taken before breakfast or right before the first meal, and it is very important not to skip meals after taking it. Initial dosage for monotherapy starts at 1 mg of Glimepiride once daily, and can be increased by 1 mg at intervals of 1–2 weeks. Generally, when doses of 4 mg or more are given, additional effects are minimal, but some patients may show better metabolic control with doses of up to 6 mg (or 8 mg). If 4 mg per day is ineffective, consider switching to insulin therapy first, otherwise consider combining with insulin or other oral antidiabetic medications.

This medication should not be used in patients with insulin-dependent diabetes or diabetic ketoacidosis, or in patients who are in a coma. It should also not be given to people who are allergic to this medication or sulfonylurea drugs, or in patients with severe liver or kidney dysfunction. Pregnant or breastfeeding women should not use this medication. In patients with severe infections, post-operative conditions, or severe trauma, insulin treatment is recommended, and this medication should be avoided. Patients with gastrointestinal disorders should be cautious as food absorption may be unstable, increasing the risk of hypoglycemia. This medication contains lactose, so it should not be taken by patients with lactose intolerance or galactose absorption disorders. During initial dosing, there is a high risk of hypoglycemia, so special caution is necessary in cases of irregular meals, poor nutritional status, alcohol consumption, kidney or liver dysfunction, or in elderly patients. Symptoms of hypoglycemia include headache, severe hunger, nausea, fatigue, anxiety, confusion, dizziness, drowsiness, and loss of consciousness, and immediate action should be taken if these symptoms occur. While taking this medication, blurred vision, dyspepsia, abnormal liver function, blood abnormalities, and allergic reactions may occur, so any unusual symptoms should be reported to a doctor. It is very important to combine dietary and exercise therapy for blood sugar control, and to immediately consume sugar if hypoglycemia occurs. If taken with other drugs, interactions may occur, so be sure to inform your doctor or pharmacist of any medications being taken. If pregnant or breastfeeding, it is advisable to switch to insulin therapy as this medication may be harmful to the fetus or newborn. In the case of overdose, hypoglycemia may worsen, and immediate medical treatment should be sought. This medication should be stored out of reach of children.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, shortness of breath, hypotension, anaphylaxis, angioedema, Stevens-Johnson syndrome, abnormal liver function (bile secretion disorder, jaundice, hepatitis), severe hypoglycemia (including coma and loss of consciousness), thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, agranulocytosis, pancytopenia, allergic vasculitis, hyponatremia.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• diminished agility or motivation

This medication should be stored in a closed container to protect it from air or moisture. It is best to maintain storage temperatures between 1°C and 30°C.

Appearance

Green oval tablet

Package unit

30 tablets/bottle, 100 tablets/bottle