Kramoxin Tablets 187.5 mg (Amoxicillin - Clavulanate Potassium (2:1))

Adult dose

Adults and children aged 12 years and older or those weighing over 40 kg should take 250 mg/125 mg of amoxicillin/potassium clavulanate orally three times a day every 8 hours, and in cases of severe and respiratory infections, the dose may be increased to 500 mg/125 mg. In cases of renal impairment, adjust the dosage according to creatinine clearance. - Creatinine clearance of 10 to 30 mL/min: 250 to 500 mg of amoxicillin orally every 12 hours.

Child dose

Children aged 12 years and older or those weighing over 40 kg should take 250 mg/125 mg orally three times a day every 8 hours, same as adults. In cases of renal impairment, dosage should be adjusted using the same method as adults.

This medication is a beta-lactam antibiotic and should not be administered to patients with allergies to penicillin or cephalosporin drugs. Patients with infectious mononucleosis or lymphocytic leukemia should be cautious since there is a higher risk of rash while taking this medication. Patients with poor liver function or a history of liver issues related to this medication or penicillin should use this medication with particular caution. In patients with moderate to severe renal impairment, the blood concentration of this medication may increase, thus the dosing interval needs to be adjusted. Patients with an allergic disposition or symptoms of asthma, urticaria should consult with a physician before taking the medication. Gastrointestinal symptoms may include diarrhea, vomiting, and abdominal pain; if severe diarrhea or blood in stools occurs, medication should be stopped immediately and medical attention sought. Symptoms of liver dysfunction, such as jaundice and hepatitis, may rarely occur, particularly in the elderly and males. Serious allergic reactions can rarely manifest as skin rashes, difficulty breathing, and shock, and immediate medical treatment should be sought if these symptoms occur. This medication may affect the results of blood tests, so regular testing is necessary, and kidney and liver function as well as blood condition should be periodically reviewed during prolonged use. Pregnant women in the early stages or nursing mothers should use this medication with caution, especially avoiding use during the first trimester of pregnancy. This medication is only recommended for children aged 12 years and older or those weighing 40 kg or more, and the elderly should be cautious due to a higher risk of side effects from reduced body function. There may be interactions with other medications, so especially when taking anticoagulants, probenecid, or allopurinol, consultation with a physician is necessary. In cases of overdose, symptoms such as vomiting, diarrhea, renal failure, and seizures might occur, and in such cases, immediate medical attention should be sought. The medication should be stored in a dry place below 25 degrees Celsius, and the efficacy may vary depending on the storage conditions.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, paleness, severe rash with high fever, blisters, peeling of the skin, pain in mucous membranes of mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory issues accompanied by cough and fever, yellowing of skin or eyes (jaundice), severe fatigue, sudden and severe headache, lightning headache, seizures, confusion, vision abnormalities, paralysis, urination problems

Mild side effects

Diarrhea, pseudomembranous colitis, dyspepsia, stomatitis, gastritis, glossitis, black hairy tongue, nausea, vomiting, loss of appetite, abdominal pain, abdominal distension, constipation, colonic pain, acid reflux, soft stools, dry mouth, acute pancreatitis, candidiasis, colitis, bloody stools, itching, erythema multiforme, mucocutaneous syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), vesicular exfoliative dermatitis, acute generalized exanthematic pustulosis, eosinophilia, systemic symptoms, vascular manifestations

This medication is contained in a sealed container to prevent moisture. It should be stored in a cool temperature between 1 and 25 degrees and it is essential to keep it in a dry area with low humidity.

Appearance

White or nearly white round film-coated tablets

Package unit

100 tablets (10 tablets/PTP x 10)