Glimeryl Tablets 2 mg (Glymepiride)

Adult dose

Adjust individually for each patient. Swallow without chewing with more than 1/2 cup of water. Administer orally once daily. Should be taken before breakfast or right before the first meal. The initial dose starts at 1 mg of glymepiride once daily, which can be increased by 1 mg at intervals of 1-2 weeks. Generally, doses above 4 mg yield little additional effect; however, a maximum of 6 mg may be considered.

This medication should not be used in patients with insulin-dependent diabetes, diabetic ketoacidosis, or who are in a comatose state. Additionally, patients who have had allergic reactions to this medication or its components, as well as sulfonylureas or sulfonamides, should avoid administration. There is no experience in using this medication in patients with severely impaired liver or kidney function, hence a switch to insulin therapy is recommended. It should not be administered to pregnant women or breastfeeding women due to potential harm to the fetus or newborn. In cases of severe infection, pre- or post-surgery, or in severely traumatized patients, insulin treatment is necessary and this medication should not be used. In patients where food absorption is decreased due to diarrhea or vomiting, caution is needed for the risk of hypoglycemia. During the initial dosing, there is a high risk of hypoglycemia, so blood sugar levels need to be closely monitored, especially in elderly patients, those with poor nutritional status or irregular meals, and those with imbalanced exercise and meal intake. Caution is also necessary for those who consume alcohol, have impaired kidney and liver function, or are taking multiple medications, as the risk of hypoglycemia may increase. Symptoms of hypoglycemia may include headache, severe hunger, nausea, fatigue, confusion, drowsiness, and loss of consciousness; in severe cases, seizures or coma may occur, requiring immediate treatment. Various side effects such as blurred vision, dyspepsia, liver dysfunction, blood abnormalities, and allergic reactions may occur, hence any unusual symptoms should be reported to a doctor or pharmacist promptly. This medication should be taken regularly alongside dietary and exercise therapies, and should immediate sugar intake be required during a hypoglycemic episode.

Serious side effects

• Hives
• severe swelling (edema)
• difficulty breathing
• severe allergic reactions
• severe rashes with fever
• blisters
• skin peeling
• oral/ocular mucosal pain
• severe dermatological reactions
• jaundice

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• reduced concentration
• decreased agility or motivation

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture. It is important to maintain a storage temperature between 1 to 30 degrees Celsius to preserve the drug's efficacy and safety over time.

Appearance

Green rectangular tablets

Package unit

Domestic use - 100 tablets/bottle, Domestic use - 30 tablets/bottle, Export use - 100 tablets/box [(10 tablets/PTP × 10)]