Clarithromycin Dry Syrup 125mg/5mL (Clarithromycin)

Adult dose

In patients with renal failure whose creatinine clearance is 30mL/min/1.73m2 or less, reduce the dose by half. Do not administer this drug to these patients for more than 14 days. Food does not affect the bioavailability of this drug; therefore, it may be administered without regard to meals. It may be taken with food or milk.

Child dose

The usual pediatric dose is 7.5mg per Kg of body weight every 12 hours (15mg/Kg/day). The usual duration of treatment is 5～10 days. ○ Mycobacterial infections Administer 7.5～15mg per Kg of body weight every 12 hours (15～30mg/Kg/day) to children. Continue treatment if clinical improvement is observed. Do not exceed 500mg (potency) per dose, twice daily, as clarithromycin (potency). Administer in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin.

This medication should not be administered to certain patients. For instance, individuals allergic to any ingredients contained in this medication or those with a history of hypersensitivity to certain antibiotics should not use it. Patients taking medications affecting heart rhythm, those with heart disease, or patients with severely reduced liver or kidney function should also avoid this medication. It is also advised that pregnant or breastfeeding women do not use this medication. When using this medication, patients with compromised liver or kidney function, the elderly, and patients with heart disease should be especially cautious. Furthermore, those taking other antibiotics or specific medications should consult a physician or pharmacist to avoid potential drug interactions. This medication may cause various side effects, such as allergic reactions, gastrointestinal disturbances, liver function abnormalities, skin rashes, neurological issues, so any unusual symptoms should be reported to healthcare professionals immediately. Caution is warranted for those on long-term or high-dose therapy due to the risk of hearing impairment, tinnitus, or muscle issues. Interactions with other medications can be significant, especially with those that affect blood coagulation, heart-related medications, or drugs metabolized by the liver. Pregnant or breastfeeding women are advised against use, as it may affect the fetus or infant. If unavoidable, consultation with a healthcare professional is necessary before proceeding. Dosing in pediatric or elderly patients should be approached with caution, particularly for the elderly with reduced kidney function, where dosage adjustments may be necessary. During the course of this medication, it is important to regularly check liver and kidney function as well as blood tests for any abnormalities. In the case of overdose, gastrointestinal symptoms or neurological issues may present, thus immediate medical attention is crucial.

Shock, anaphylactic symptoms, dyspnea, seizures, erythema, rash, itching, urticaria, skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, bloating, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, anorexia, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, abdominal pain, frequent diarrhea, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltrate, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, seizures, tremors, numbness, behavior changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash with eosinophilia and systemic symptoms, jaundice, hepatocellular or cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, increased LDH, elevated ALP, increased total bilirubin, anorexia, jaundice, dark urine, pruritus, abdominal tenderness, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, elevated CPK, increased myoglobin in blood and urine, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de Pointes, malaise, headache, taste disturbance, hearing loss, paresthesia, arthralgia, myalgia, olfactory disorders, tinnitus, hearing impairments, hypoglycemia, tinnitus, hearing loss, vomiting, nausea, abdominal pain, purpuric rash, acute pancreatitis, increased amylase, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reaction, angioedema, decreased appetite, insomnia, nervousness, tinnitus, psychotic disorder, confusional state, abnormal dreams, akathisia, non-vestibular dizziness, drowsiness, tremor, vestibular dizziness, hearing impairment, cardiac arrest, atrial fibrillation, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, flatulence, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyl transferase, liver failure, vesicular dermatitis, papular rash, acne, Henoch-Schonlein purpura, acute generalized pustular rash, muscle cramping, musculoskeletal stiffness, myopathy, nephritis, injection site thrombophlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color, changes in mental state, compulsive behavior, hypokalemia, hypoxemia

This medication is susceptible to air and moisture, hence it must be stored in a tightly sealed container. Maintaining storage temperatures between 1°C and 30°C at room temperature is essential.

Appearance

White to off-white granule powder

Package unit

100 milliliters per bottle