Zacutex Dry Syrup 156.25 mg / 5 mL (Amoxicillin·Clavulanate Potassium)

Adult dose

For mild to moderate infections such as recurrent tonsillitis and other upper respiratory infections, lower respiratory infections, urinary tract infections, and skin and soft tissue infections, take 20 mg/5 mg of amoxicillin/clavulanate potassium per kg of body weight, divided into 3 doses per day. For more severe infections such as otitis media, sinusitis, lower respiratory infections like bronchopneumonia, and severe urinary tract infections, take 40 mg/10 mg of amoxicillin/clavulanate potassium per kg of body weight, divided into 3 doses per day.

Child dose

There is insufficient clinical data regarding the use of the 4:1 syrup in children under 2 months. In cases of renal impairment, appropriate dosage reduction should be made.

This medication should not be used in patients who have had hypersensitivity reactions to specific components or beta-lactam antibiotics. Especially, patients who have experienced anaphylaxis or severe skin reactions should not be administered this drug. Additionally, patients with infectious mononucleosis or lymphocytic leukemia are at a heightened risk for rash if this drug is used. Patients with a history of liver dysfunction or jaundice should avoid this drug as symptoms may recur. This medication contains lactose, making it unsuitable for patients with lactose intolerance or genetic digestive disorders. Care should be taken when administering this drug to patients with impaired liver function or severe kidney impairment due to the increased risk of side effects from elevated concentrations. Patients with known allergies, those receiving parenteral nutrition, elderly patients, and those in poor overall health should also be administered with caution. Patients exhibiting gastrointestinal symptoms like vomiting or diarrhea may not properly absorb the medication, necessitating careful attention. This drug may cause gastrointestinal adverse reactions such as diarrhea, abdominal pain, vomiting, and in severe cases, conditions like pseudomembranous colitis may occur. Liver function abnormalities may rarely develop, so liver function tests are recommended for prolonged use. Should any skin rashes or itching occur, or if severe skin reactions such as Stevens-Johnson syndrome occur, discontinue use immediately. Hematological adverse reactions such as leukopenia or anemia have been reported, so appropriate testing should be conducted if any abnormal symptoms arise. Neurological symptoms such as anxiety, confusion, and seizures may rarely occur; notify medical personnel if symptoms manifest. Since kidney function may deteriorate, regular examinations are necessary for patients with renal disease. This drug can affect the intestinal bacterial balance, potentially leading to infections like candidiasis. Symptoms of vitamin K deficiency may occur, necessitating caution for patients with a tendency to bleed. It is generally advisable not to use this medication during pregnancy, particularly in the first three months, and care should be exercised during nursing to avoid side effects in infants. Young children, especially newborns under 2 months, should be treated with caution as safety has not been established. Elderly patients, due to declining physical function, are at higher risk for side effects and should have dosage and intervals carefully adjusted with close monitoring. When using this drug, it is essential to discuss any history of allergies and current health status with healthcare professionals and to take the medication exactly as prescribed. Furthermore, because of the potential for drug interactions, it is necessary to inform of any other medications being taken. If any abnormal symptoms appear after taking the medication, seek medical attention immediately.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reaction, high fever with severe rash, blisters, skin peeling, pain in mucous membranes of mouth/eyes, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough and fever, breathing difficulties, jaundice (yellowing of the skin or eyes), extreme lethargy, liver abnormalities (jaundice), sudden and

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain

This medication may be sensitive to air and moisture; therefore, it should be stored in a tightly sealed container. Additionally, it should be kept in a cool, dry place below 25 degrees Celsius to maintain its efficacy for an extended period.

Appearance

Dry syrup preparation to be dissolved in use, in white to pale yellow powder form

Package unit

50 milliliters / bottle