Cefdone 1g (Cefepime Sodium)

Adult administration

For Gram-positive bacterial infections, administer 1-2 g (potency) intravenously divided into 2-3 doses daily; for Gram-negative bacterial infections, administer 3-4 g (potency) intravenously divided into 2-3 doses daily. In cases of life-threatening infections or infections caused by moderately susceptible organisms, the dose may be increased to 6 g (potency) per day. Preparation of injection: For intravenous administration, dissolve 1 g (potency) of this medication in 5 mL of sterile water.

This medication should not be used in patients with hypersensitivity to cephalosporin antibiotics. It is particularly not safe for administration to premature infants and newborns. Caution is advised in pregnant women during the first trimester or patients with renal and liver dysfunction. Care is also required for patients with hemophilia or thrombocytopenia, as well as patients with gastrointestinal ulcers. Patients who have difficulty with oral intake, are receiving parenteral nutrition, elderly patients, and those in poor general health should be closely monitored for vitamin K deficiency symptoms. Mild hypersensitivity reactions such as transient headache, dizziness, and nausea may occur with this medication. Rarely, skin rashes, fever, or severe allergic reactions such as anaphylaxis may occur; if these symptoms arise, the medication should be discontinued immediately and appropriate treatment should be initiated. Liver function tests may show elevated results, so it is advisable to regularly check liver status. A transient decrease in white blood cell count may occur, so blood tests should be conducted to monitor this. If abdominal pain or frequent diarrhea or bloody stools are present, it could indicate severe colitis such as pseudomembranous colitis, and the use should be stopped immediately. Respiratory symptoms such as fever, cough, and difficulty breathing may indicate interstitial pneumonia or PIE syndrome, necessitating prompt action. Rare occurrences of dysbiosis such as stomatitis or candidiasis may happen. There may also be signs of vitamin K deficiency leading to bleeding tendencies or symptoms of vitamin B group deficiency, therefore, symptoms should be carefully monitored. To prevent the emergence of resistant organisms, it’s important to conduct susceptibility testing and to administer for only the minimum required duration. Adequate medical history and skin reaction testing are recommended prior to administration to prevent allergic reactions. Patients should be closely observed after administration in a stable condition to prepare for severe reactions like shock. Caution is warranted when used in combination with other antibiotics or drugs that may affect renal function, and when used with drugs that may affect blood coagulation, careful monitoring is needed. When breastfeeding, this medication may transfer in small amounts to breast milk, so caution is advised. Lastly, this medication should not be mixed for injection with aminoglycoside antibiotics.

Serious side effects

Anaphylaxis (severe allergic reaction), severe rash accompanied by skin rash and fever, blisters, skin peeling (severe dermatologic adverse reactions), difficulty breathing, abnormal chest X-ray findings, interstitial pneumonia associated with eosinophilia, PIE syndrome (respiratory problems), severe colitis accompanied by bloody stools, bleeding tendency (severe swelling or abnormal urination)

Mild side effects

Transient mild headache, dizziness, nausea, skin rash, fever, increased AL-P, GOT, GPT, transient leukopenia, vomiting, loss of appetite, abdominal pain, frequent diarrhea, stomatitis, candidiasis, symptoms of vitamin K deficiency (hypoprothrombinemia, bleeding tendency), symptoms of vitamin B group deficiency (stomatitis, glossitis, loss of appetite, neuritis)

This medication should be stored in a sealed container to protect it from air exposure, ideally at room temperature between 1 and 30 degrees Celsius. This storage helps maintain the drug's effectiveness and prevents deterioration.

Appearance

A colorless transparent vial filled with white to pale yellow powder

Package unit

10 vials