Kramax Duo Syrup (Amoxicillin·Clavulanate Potassium)

Adult dose

In cases of recurrent tonsillitis and other upper respiratory infections, lower respiratory infections, urinary tract infections, and skin/soft tissue infections of mild to moderate severity, it is generally prescribed at 25 mg/3.6 mg per kg of body weight, divided into two doses daily. For severe infections such as otitis media, sinusitis, and lower respiratory infections like bronchopneumonia or urinary tract infections, it is generally prescribed at 45 mg/6.4 mg per kg of body weight, divided into two doses daily. To minimize potential gastrointestinal intolerance.

Child dose

7:1 syrup is not suitable for children under 2 months old. Pediatric patients with renal failure should not use 7:1 syrup.

This medication should not be used in patients who have a hypersensitivity to specific components or beta-lactam antibiotics. Extra caution is warranted in patients with infectious mononucleosis or lymphocytic leukemia, as there is an increased risk of rash. Furthermore, patients with a history of liver dysfunction due to this medication or penicillin-related drugs should not be treated due to the risk of recurrence. It contains lactose, so it should not be given to patients with lactose intolerance or related genetic disorders. Patients with poor liver function or moderate to severe kidney impairment should use this medication cautiously, as drug concentration may increase. Allergic individuals or those with gastrointestinal issues such as vomiting and diarrhea should also use it with care. Elderly patients or those in poor general health should be monitored due to risks of vitamin K deficiency and bleeding. This medication may cause gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain, and in rare cases, severe colitis or pancreatitis may occur. Abnormal liver function tests or jaundice symptoms may also present, as well as skin rashes or severe allergic reactions. Blood tests may rarely reveal leukopenia or thrombocytopenia, and any unusual symptoms should be discussed immediately with healthcare providers. This medication can rarely lead to serious allergic reactions like anaphylactic shock; thus, patient status should be closely monitored post-administration. Serious gastrointestinal diseases such as pseudomembranous colitis can occur, so if severe diarrhea or abdominal pain arises, discontinuation of the drug and treatment should be sought immediately. Long-term use may lead to the development of resistant bacteria, so it is essential to use it only for the necessary duration. Patients with liver and kidney dysfunction require regular testing, particularly if treatment extends beyond 14 days. This medication may interact with other drugs, especially anticoagulants or specific antibiotics; inform healthcare providers before use. During pregnancy, the initial three months should be avoided, and caution is advised while breastfeeding due to potential side effects on the infant. The safety of this drug in children, particularly in newborns under 2 months, has not been established, so care is needed for use. Elderly individuals have an increased risk of side effects due to decreased physiological function, requiring careful adjustment of dosage and administration intervals. This medication should be shaken well before use, and stored in a refrigerator after preparation to be consumed within 7 days. In case of overdose, symptoms such as vomiting, diarrhea, rash, and convulsions may occur, necessitating prompt notification and appropriate treatment from medical personnel.

Serious side effects

Rash, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe allergic reactions, high fever with severe rash, blisters, skin peeling, pain in the mucous membranes of the mouth/eyes, severe skin adverse reactions, difficulty breathing or shortness of breath, asthma attacks, respiratory abnormalities associated with cough + fever, yellowing of the skin or eyes (jaundice), extreme lethargy, liver issues (jaundice), sudden and extreme reactions.

Mild side effects

Diarrhea, pseudomembranous colitis, dyspepsia, stomatitis, gastritis, glossitis, nausea, vomiting, loss of appetite, abdominal pain, bloating, constipation, colonic pain, hyperacidity, loose stools, xerostomia, candidiasis, severe colitis with blood in stool, hepatitis, elevated AST, ALT, ALP, LDH, serum bilirubin, pruritis, erythema multiforme, mucocutaneous syndrome, toxic epidermal necrolysis, vesiculobullous dermatitis, acute generalized exanthematous pustulosis, eosinophilia.

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It must be kept in a cool, dry place below 25 degrees Celsius to maintain its effectiveness.

Appearance

White or yellowish powder used as syrup when dissolved.

Package unit

50 mL/bottle, 500 mL/bottle