Hibron Jau Prefilled (Sodium Hyaluronate)

Adult administration

As sodium hyaluronate, 25 mg is administered once a week for 5 consecutive weeks into the knee joint or shoulder joint (joint cavity, subacromial bursa, or long head of the biceps tendon), adjusting the frequency of administration based on symptoms.

This drug should not be used by certain patients. First, patients who have had an allergic reaction to this drug or its ingredients should not be administered this product. In addition, patients with skin diseases or infections in the joint area should not use this drug. Patients with liver dysfunction or a history of liver disease should use this medication with caution. Patients allergic to avian proteins should also refrain from using this medication. When using this drug, one must always be mindful of the potential for side effects. Rarely, severe allergic reactions or shock may occur, thus the patient's condition should be closely monitored after administration. If swelling around the face or eyes, rash, or itching appears, administration should be immediately discontinued. Temporary pain, swelling, redness, or heat may occur at the injection site, and if these symptoms are severe, appropriate treatment should be received. Moreover, systemic symptoms such as nausea, vomiting, fever, or headache may occur. Administering this drug to joints with severe inflammation may aggravate symptoms, hence it is advisable to use it after the inflammation subsides. After administration, stabilizing the joint and avoiding excessive movement is recommended. If the drug leaks outside the joint, it may cause pain, so it should be precisely injected into the joint. Patients with inflammatory arthritis such as rheumatoid arthritis or gout may experience temporary increases in inflammation, so caution is advised. Avoid intense physical exercise or prolonged weight-bearing activities for 48 hours after administration. The safety and efficacy of this drug have not been confirmed when used with other intra-articular injections, so it is advisable not to mix them. Pregnant women or those who may become pregnant should use this drug cautiously as its safety has not been established and should only be used when the therapeutic benefits outweigh the risks. Nursing mothers should avoid breastfeeding during administration, as the drug may be transmitted through breast milk. The safety of this drug in pediatric patients has also not been sufficiently confirmed, so it should only be used cautiously when absolutely necessary. Elderly patients may have decreased bodily functions, hence more caution should be exercised during administration. Aseptic conditions must be strictly maintained during injection, and if symptoms do not improve, administration should be stopped within 5 doses. If there is fluid accumulation in the joint, it is advisable to aspirate the fluid before administration. This drug is not intended for intravenous administration or ophthalmic use. Care should be taken in the selection of injection needles and the method of aspirating the solution due to its high viscosity, and after shaking the ampoule to collect the solution, it should be slowly drawn into the syringe. When breaking the ampoule, it is safer to wipe it clean to prevent foreign material from entering. Care must be taken as this drug can react with disinfectants such as benzalkonium chloride or chlorhexidine to form precipitates. This drug is for single use; any unused drug after opening should be discarded.

Serious side effects

• Urticaria
• swelling (facial, eyelids, etc.)
• shock

Mild side effects

• Facial flushing
• itching
• pain
• swelling
• redness
• warmth
• severe localized pressure
• petechiae
• nausea
• vomiting

This drug may be sensitive to light, therefore it should be stored in an opaque, sealed container to prevent light exposure. Additionally, it is important to store the drug at room temperature, between 1 degree and 30 degrees Celsius, to maintain its efficacy.

Appearance

Injection filled in a prefilled syringe made of glass or plastic, with a colorless, transparent viscous solution sealed with rubber caps at both ends.

Package unit

5 syringes (2.5 mL each)