Unitra Injection 500 mg (Tranexamic Acid)

Adult dosage

For capsules, tranexamic acid is typically administered as 750-2000 mg divided into 3-4 oral doses per day for adults. For injection, tranexamic acid is usually administered as 250-500 mg divided into 1-2 intravenous or intramuscular injections per day for adults. For bleeding during or after surgery, 500-1000 mg may be administered intravenously once or 500-2500 mg via intravenous drip as needed. Adjust according to age and symptoms.

This drug poses a risk of glass particles being mixed in, so care must be taken when opening the ampoule. Extra caution is required when administering it to children and the elderly. It should not be used in patients receiving thrombin or those at risk of thromboembolism, or in patients allergic to this drug or its components. Additionally, it should not be administered directly around the spine. Use with caution in patients with existing thrombosis or those at risk of thromboembolism, in patients with restricted mobility post-surgery, in those with impaired kidney function, and in patients with certain coagulation disorders. Rarely, shock or allergic reactions may occur during use, so if any abnormal symptoms arise, administration should be stopped immediately, and appropriate treatment should be obtained. Temporary visual disturbances, gastrointestinal symptoms, drowsiness, and headaches may occur. During cardiovascular surgery, convulsions may occur, and severe side effects may present due to improper administration, so care is required. Combining it with other drugs that promote thrombus formation increases risk, so consult an expert if using in combination. When used with hormonal contraceptives, the risk of thrombus may increase, and alternative contraceptive methods are recommended. Pregnant women should use it cautiously as it can cross the placenta, and while it is expected to have little impact on breastfeeding infants, caution is still necessary. Elderly patients may have weakened physical function, so careful dose adjustment and monitoring are required during use. In cases of overdose, symptoms such as nausea, vomiting, and low blood pressure may occur, necessitating sufficient fluid intake and renal function support. This drug should be administered slowly intravenously; rapid administration can rarely cause symptoms such as nausea, chest discomfort, palpitations, and dizziness. Long-term high-dose administration has been reported to cause retinal changes, and mixing with certain injectable drugs can lead to drug interactions, so follow expert guidance when using in combination.

Serious side effects

• Shock
• thromboembolism
• ureter obstruction due to hematuria
• convulsions
• seizures

Mild side effects

• Itching
• rash
• flushing
• temporary color vision disturbances
• nausea
• vomiting
• diarrhea
• drowsiness
• headache
• chest discomfort

This medication should be stored in a sealed container to prevent air ingress and at room temperature between 1°C and 30°C. Proper storage will maintain the drug's efficacy and prevent deterioration.

Appearance

For domestic use, export type 1: a colorless and transparent liquid contained in a colorless ampoule. Export type 2: an ampoule containing a colorless clear liquid.

Package unit

5 milliliters × 10 ampoules