Innoen Dopamine Hydrochloride Premix 160mg Injection

Adult administration

Administer dopamine hydrochloride by intravenous injection at a dose of 2-5 µg/kg/min. In severe cases, it can be increased to 5-10 µg/kg/min up to 20-50 µg/kg/min by intravenous injection. Adjust according to age and symptoms. Prior to administration, transfuse blood or plasma to maintain the venous pressure at 10-15 cmH₂O and pulmonary wedge pressure at 14-18 mmHg. If administering over 50 µg/kg/min, urine output should be monitored.

This medication should be used with reduced dosage in patients who have previously taken monoamine oxidase inhibitors. It is preferable not to use in children due to insufficient information on safety and appropriate dosage. Mixing with alkaline solutions may cause the medication to lose its efficacy, so do not mix with alkaline solutions other than 5% dextrose injection. Patients with certain conditions, such as pheochromocytoma, uncontrolled tachyarrhythmias, ventricular fibrillation, hyperthyroidism, and closed-angle glaucoma, should not use this medication. Solutions containing dextrose may be contraindicated in patients with starch allergies, so caution is needed. Patients with peripheral vascular disorders and those allergic to sulfites should use this medication with care, and asthmatic patients should be especially cautious. Dextrose-containing solutions should not be administered with blood, and care should be taken for fluid overload and electrolyte imbalance during intravenous infusion. Excessive administration of solutions without potassium may cause severe hypokalemia. This medication may cause various side effects such as cardiac arrhythmias, peripheral ischemia due to vasoconstriction, blood pressure changes, gastrointestinal symptoms, skin reactions, headaches, anxiety, and injection site abnormalities, so patient conditions should be closely monitored. In shock states, intravenous fluids, blood transfusions, and respiratory management should be combined as necessary, and if blood volume is insufficient, blood volume should be replenished before medication administration. During administration, closely monitor urine output, cardiac output, and blood pressure, and consider dosage adjustment or discontinuation if any abnormal signs are observed. If there are conditions like hypoxia or acidosis, correct them first before administration, and sudden discontinuation may cause hypotension, so it should be tapered gradually. Diabetic patients should be cautious using solutions containing dextrose, and regular checks of fluid and electrolyte balance should be made during long-term treatment. To prevent tissue damage at the injection site, administer through a large vein, and take immediate appropriate action if the medication leaks outside the blood vessel. There are many drug interactions, so caution is needed when used with anesthetics, antidepressants, sympathomimetics, blockers, etc. During pregnancy, it should only be used when the benefits outweigh the risks to the fetus, and during lactation, it is advisable to avoid use or discontinue breastfeeding. In children and the elderly, dosage and response should be carefully adjusted, and in case of overdose, administration should be discontinued or alpha blockers should be used to stabilize the condition. The drug is sensitive to heat and oxidants, so care should be taken in storage and handling, and the state of the solution should be checked before use; do not use if abnormalities are found.

Serious side effects

• Breathing difficulties, asthmatic attacks, respiratory distress → respiratory problems.
• Severe edema accompanying hypertension.
• Severe edema or abnormal urination.
• Severe increase in blood pressure.
• Tissue necrosis and scabbing due to extravascular leakage.
• Severe edema.
• Hypokalemia.
• Tissue necrosis due to extravascular leakage.
• Severe allergic reactions with a possibility of sulfite anaphylaxis.
• Severe hypertension.

Mild side effects

• Ventricular extrasystole, atrial fibrillation, ventricular tachycardia, etc.
• Changes in limb color and temperature due to peripheral vasoconstriction.
• Precordial pulse, tachycardia, angina, palpitations, hypotension, hypertension, ventricular arrhythmias, ectopic beats, angina pain, vascular constriction, abnormal conduction, bradycardia, QRS widening, hypernitrogenemia, blood pressure increase.
• Nausea, vomiting, abdominal distension, abdominal pain, paralytic ileus.
• Hair loss.
• Headaches, anxiety, phlebitis, injection site necrosis, and numbness.

This medication should be stored in a sealed container to prevent air or moisture from entering. It is also advisable to avoid direct sunlight and store at room temperature.

Appearance

A colorless or faint yellow transparent injection solution filled in a colorless transparent plastic container for injection.

Package unit

500 milliliters/box