Glupa Tablets 850 mg (Metformin Hydrochloride)

Adult dose

The adult dosage is administered 2-3 times a day, 500mg each time, taken with meals. The dosage may be increased gradually by 500mg weekly, with a maximum of 2550mg. For dosages up to 2000mg, it is typically divided into two doses taken in the morning and evening. If the dose exceeds 2000mg, it should be taken in three portions.

Child dose

Children aged 10 years and older and adolescents should take 500mg once a day during or just after meals. After a week, blood sugar levels should be measured and the dosage adjusted, with a maximum daily dose of 2000mg.

This medication can cause severe lactic acidosis or hypoglycemia and should not be administered, especially to patients with impaired renal function or those suffering from acute diseases. Do not use in patients with moderate or severe renal impairment, dehydration, serious infections, acute myocardial infarction, or sepsis, as these conditions can affect renal function. It is also safe not to administer this medication to patients with acute or unstable heart failure. Treatment with this medication should be suspended before and after examinations using iodinated contrast agents, and can only be resumed after renal function has returned to normal. Administration is contraindicated in patients with hypersensitivity to this drug or other biguanides, in patients with type 1 diabetes, and in those with diabetic ketoacidosis. In patients with severe infections, severe traumatic systemic disorders, preoperative or postoperative patients, malnutrition, liver dysfunction, pulmonary embolism, and severe respiratory dysfunction, treatment with this medication should be temporarily suspended or used with caution. This medication can cause rare but serious side effects called lactic acidosis, so patients and caregivers should immediately inform healthcare professionals if they experience nonspecific symptoms such as fatigue, muscle pain, difficulty breathing, or abdominal pain. Gastrointestinal symptoms such as diarrhea, nausea, vomiting may commonly occur, and while these symptoms are usually temporary, treatment can be temporarily suspended in case of severe symptoms. Since this medication is excreted through the kidneys, renal function should be regularly monitored, and extra caution should be taken, particularly in older adults or those with renal impairment. Excessive alcohol intake may affect this medication and lactate metabolism, increasing the risk of lactic acidosis, so it should be avoided during treatment. In the case of unstable blood sugar control, especially in stressful situations such as infections or surgeries, treatment may be temporarily suspended, and insulin therapy may be initiated. This medication crosses the placenta; therefore, when used during pregnancy, the fetal growth status must be closely monitored, and it should not be used in pregnant women at risk of placental insufficiency or preeclampsia. In nursing mothers, this medication is secreted into breast milk, so they should consult with a physician to decide whether to discontinue breastfeeding or the medication. Use in children and adolescents should be carefully considered, especially in those under 10 years of age, as special precautions are necessary. In cases of overdose, lactic acidosis can occur which requires immediate medical intervention, and the drug can be removed via hemodialysis. Because this medication has numerous interactions with other drugs, patients taking other medications should inform their healthcare providers and should regularly monitor blood sugar and renal function. This medication does not cause weight gain and helps in blood sugar control and prevention of diabetes complications with long-term use. Keep out of reach of children, and ensure that it is not transferred to another container.

Serious side effects

Lactic acidosis (fatigue, muscle pain, difficulty breathing, weakness, abdominal pain, body temperature drop, hypotension, bradyarrhythmias), severe allergic reactions (rash), liver abnormalities (liver dysfunction, jaundice), hypoglycemia (severe delayed hypoglycemia)

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain), metallic taste, rash, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver dysfunction, hypoglycemia, megaloblastic anemia

This medication may be sensitive to air or moisture; therefore, it should be stored in a tightly sealed container. It is important to maintain the storage temperature between 1 degree and 30 degrees Celsius to safely preserve the medication's effectiveness.

Appearance

White rectangular film-coated tablet

Package unit

For domestic use: 500 tablets/bottle, 100 tablets, 30 tablets/bottle; for export: 500 tablets/bottle, 60 tablets/bottle, 60 tablets (10 tablets/PTPX6)