Ceftil Tablet 250 mg (Cefuroxime Axetil)

Adult dose

For optimal absorption, take after meals. 3. Patients with renal impairment Cefuroxime is primarily excreted by the kidneys. For patients with significantly impaired renal function, it is recommended to reduce the dose of cefuroxime as shown below to compensate for delayed excretion. ≥ 30 mL/min/1.73m2: No dose adjustment required (standard dose: 125mg-500mg per dose, twice daily) 10 - 29 mL/min/1.73m2: Administer a standard single dose every 24 hours < 10 mL/min/1.73m2: Administer a standard single dose every 48 hours Patients on hemodialysis: Administer an additional standard single dose at the end of each dialysis session

Child dose

Children aged 12 years and older - Most infections: Administer 250mg per dose twice daily. Children aged 12 years and older - Severe lower respiratory tract infections, pneumonia, severe infections, or suspected infections caused by less susceptible organisms: Administer 500mg per dose twice daily. Children aged 12 years and older - Urinary tract infections: Administer 250mg per dose twice daily. Children aged 12 years and older - Uncomplicated gonorrhea: Administer a single dose of 1g. Children aged 12 years and older - Lyme disease: Administer 500mg per dose twice daily for 14 days (10~21 days). Children under 12 years - Most infections: Administer 125mg per dose twice daily. Children aged 2 years and older - Otitis media, severe infections: Administer 250mg per dose twice daily. Children under 12 years - Lyme disease: Administer 250mg per dose twice daily for 14 days (10~21 days). There is insufficient experience with use in infants under 3 months of age.

This drug should not be used in patients with hypersensitivity to cephalosporins. Caution should be exercised in patients with a history of allergy to penicillins or other beta-lactam antibiotics, those with allergic diathesis, severe renal impairment, patients unable to ingest orally, or the elderly. Common adverse reactions may include Candida overgrowth, changes in blood components, skin rash, headache, dizziness, dyspepsia, and diarrhea. Rarely, serious skin reactions, hepatitis, renal impairment, or bleeding tendencies due to vitamin K deficiency can occur, so immediate consultation with a healthcare provider is needed if symptoms arise. It is important to administer this drug for the minimum duration necessary to prevent the development of resistant bacteria and to carefully monitor patients for any allergic reactions, discomfort, or dizziness during treatment. Antibiotic use may lead to excessive growth of intestinal Candida or non-susceptible strains, and treatment should be discontinued if such symptoms occur. If gastrointestinal symptoms such as diarrhea or abdominal pain persist, consideration of the possibility of pseudomembranous colitis should lead to immediate cessation of treatment and further investigation. This drug may cause dizziness; caution is advised when driving or operating machinery. Pregnant or breastfeeding women should exercise caution regarding the use of this drug, and safety has not been established in children, especially infants under 3 months of age. In the elderly, adverse reactions may occur more easily due to decreased bodily function, so it is important to adjust the dosage and interval and to observe cautiously. Additionally, this drug may interact with other medications, so any concurrent medications should be disclosed to a healthcare provider. In case of overdose, serious side effects such as seizures may occur, requiring immediate medical treatment. Finally, this drug should be kept out of the reach of children, stored in its original container, as transferring it to another container may compromise its quality.

• Candidiasis hyperproliferation
• eosinophilia
• positive Coombs test
• thrombocytopenia
• leukopenia
• granulocytopenia
• erythropenia
• hemoglobin decrease
• hematocrit decrease
• hemolytic anemia

This drug should be stored in a tightly sealed container to avoid contact with air, ideally at room temperature between 1 degree and 30 degrees Celsius. Storing it this way can maintain the drug's effectiveness and prevent degradation.

Appearance

White rectangular film-coated tablet

Package unit

50 tablets/box [10 tablets/PTPX5]