Kono Pen Capsule

Adult dose

Adults aged 19 and older: Administer 1 to 2 capsules orally at 4-hour intervals. Maximum daily dose is 12 capsules.

Child dose

Children aged 13 to 18 years: Administer 1 to 2 capsules orally at 4-hour intervals. Maximum daily dose is 12 capsules. Treatment period should be limited to 3 days, unless effective pain relief is achieved.

This medication contains codeine, which is converted to morphine in the liver, leading to varying responses among patients. If symptoms such as slowed or shallow breathing occur due to rapid increases in morphine levels, the medication should be stopped immediately and a doctor should be consulted. Additionally, individuals who consume alcohol regularly should consult a doctor or pharmacist before taking this medication, as it may increase the risk of liver damage or gastrointestinal bleeding. This medication also contains a non-steroidal anti-inflammatory drug, which may increase the risks of cardiovascular disease and gastrointestinal bleeding or ulcers; caution is required. The acetaminophen component can cause severe liver damage if overdosed, so care should be taken not to consume it along with other products containing acetaminophen, and patients with impaired liver function must consult a doctor before use. Due to an increased risk of respiratory depression, individuals under 18 or those who are obese or have respiratory illnesses should avoid this medication. Using this medication in combination with other central nervous system depressants or alcohol may lead to severe sedation, respiratory depression, or coma; such combinations should be avoided unless absolutely necessary, and minimal doses for the shortest duration should be used. This medication should not be administered to patients with specific conditions such as asthma, severe liver or kidney dysfunction, head trauma, severe blood pressure issues, children, late-term pregnancy women, or nursing mothers. Moreover, patients with heart disease, respiratory depression, or liver and kidney dysfunction should use this medication carefully, and those with a history of drug dependence or alcohol addiction should also be cautious. During the course of treatment, patients should be monitored closely for abnormal reactions, and if symptoms such as skin rash, difficulty breathing, jaundice, or hematuria occur, the medication should be stopped immediately and medical personnel should be consulted. Long-term use of this medication may lead to tolerance or dependence, so continuous use for over 4 weeks is not recommended. Drowsiness or dizziness may occur with this medication, so caution is advised while driving or operating machinery, and gradual dose reduction should be considered when discontinuing use. It is advisable for women who are pregnant or may become pregnant to avoid this medication, especially during late-term pregnancy, as it may pose a risk to the fetus. Nursing mothers should discontinue breastfeeding while taking this medication due to the risk of exposure to the infant through breast milk, and should monitor the infant closely for any unusual symptoms. Children, particularly those under 12 years old or those under 18 with obstructive sleep apnea following tonsillectomy, should not use this medication. The elderly or frail patients should take this medication with caution at minimal doses due to a higher risk of side effects. In cases of overdose, serious side effects such as liver damage, respiratory depression, and kidney dysfunction may occur, requiring immediate emergency treatment. This medication should be stored out of reach of children and should not be transferred to other containers.

Serious side effects

Slow or shallow breathing, confusion, pinpoint pupils → significant adverse reactions dependence → risk of codeine dependence and abuse respiratory depression → symptoms of respiratory depression at high doses head trauma and increased intracranial pressure shock and dyspnea, generalized flushing, edema, urticaria, and anaphylactic symptoms Skin and mucous membrane syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), erythema multiforme, exfoliative dermatitis, DRESS syndrome

Mild side effects

• Constipation
• loss of appetite
• insomnia
• dizziness
• nervous exhaustion
• tinnitus
• depression
• mood changes
• drowsiness
• confusion

This medication should be stored in a tightly sealed container that is not exposed to air, ideally at room temperature between 1 and 30 degrees Celsius. This will help maintain the medication's efficacy and prevent deterioration.

Appearance

A hard capsule with a red upper portion and a white lower portion filled with white granules or powder.

Package unit

100 capsules (10 capsules/blister × 10)