Pfizer Leucovorin Injection (Calcium Levofolinate)

Adult dosage

1. Methotrexate standard therapy: Administer 6-12mg of Leucovorin intramuscularly every 6 hours, four times a day. 2. Methotrexate-Leucovorin rescue therapy: Administer 15mg intravenously every 3 hours for 9 doses and then 8 doses every 6 hours intravenously or intramuscularly. 3. Combined administration with 5-Fluorouracil (5-FU) for metastatic colorectal cancer: Administer calcium levofolinate 200mg/m² per day at minimum.

This drug is not suitable for the treatment of pernicious anemia or other megaloblastic anemias due to vitamin B12 deficiency. Even when neurological symptoms persist, caution is required as blood conditions may improve. Glass particles from the injection vial may be introduced, so the vial should be carefully handled when injecting, especially when used in children or the elderly. Women who are pregnant or breastfeeding should take special precautions, and in some cases, administration should be avoided. This drug should be used according to a doctor's instructions when used in combination with anticancer agents like methotrexate, requiring blood concentration tests to manage therapeutic effects and side effects. Regular blood tests and liver function tests should be conducted to early detect and manage adverse reactions. This drug may cause allergic reactions or injection site pain, fever, and central nervous system symptoms, so if unusual symptoms occur, consult healthcare professionals immediately. Additionally, it may interact with other medications, so it's important to inform if any other drugs are being taken. Elderly patients may have reduced physiological function, requiring more caution during administration. This drug is contraindicated for intrathecal administration, and intravenous injections should be administered slowly while monitoring calcium content. Store out of reach of children and keep it in the original container to maintain quality.

Serious side effects

• Anaphylactic reactions
• urticaria
• paralytic disorders

Mild side effects

• Vascular pain
• transient pain
• fever
• excitement
• depression
• diarrhea
• skin reactions
• skin dryness
• stomatitis
• conjunctivitis

This drug should be stored in a sealed container to avoid exposure to air and light. Additionally, it is important to store it in a cool place between 2°C and 8°C to maintain its effectiveness.

Appearance

A transparent yellow injection solution filled in a colorless transparent vial

Package unit

50mg/5mL x 1 vial, 100mg/10mL x 1 vial, 300mg/30mL x 1 vial