Pine Injection 1,000 IU/mL (Heparin Sodium)

Adult administration

Typically administered via intravenous injection or added to blood during extracorporeal circulation. The effect appears immediately after administration, but sensitivity to heparin varies among individuals; therefore, a heparin sensitivity test should be conducted before administration, and after administration, the blood coagulation time should be measured to determine the maintenance dose. Generally, the blood coagulation time is maintained for 15 to 20 minutes or longer after usage, but the dosage should be adjusted based on the individual case or therapeutic area and purpose.

This medication is a very potent drug and should only be used under the strict supervision of a physician. Special caution should be exercised when used in patients with diseases that have a high risk of bleeding, as various areas of bleeding may occur in patients receiving this medication. Benzyl alcohol contained in this medication can cause serious respiratory issues in premature or low-birth-weight infants, so caution is advised. It should not be administered to patients who have an allergy to this medication or its components, those with inappropriate blood coagulation test results, patients with a tendency to bleed, or patients with severe liver or kidney dysfunction. Patients who have undergone central nervous system or eye surgery recently, those who have received spinal or epidural anesthesia, patients with specific histories of thrombocytopenia, and neonates should also not receive this medication. Careful administration is required in patients with consumptive coagulopathy, catheterization, late-term pregnant women, those with lens hemorrhage or severe retinal lesions, patients with liver or kidney dysfunction, children, and the elderly. Monitor coagulation state frequently and carefully observe for signs of bleeding. This medication may cause side effects such as bleeding, thrombocytopenia, liver dysfunction, hypersensitivity reactions, skin issues, osteoporosis or renal suppression with long-term use. Local pain or hematoma may occur at the injection site and rarely, thrombosis or severe allergic reactions may occur; if adverse symptoms appear, contact medical personnel immediately. While using this medication, regularly verify blood coagulation test results, and if bleeding becomes severe or there is a rapid decrease in platelet count, discontinue administration. Moreover, sudden cessation of the anticoagulant effect of this medication can pose a risk of thrombosis, so dosage should be gradually reduced. Due to potential interactions with other medications taken concurrently, the risk of bleeding may increase or efficacy may change; it is essential to inform medical personnel of any medications being taken. Women who are pregnant or breastfeeding should use caution due to the risk of uterine and placental hemorrhage; while this medication is not secreted in breast milk, caution is necessary due to the presence of benzyl alcohol. Special care is needed for children and the elderly as they may have an increased risk of bleeding. Overdosage can result in hemorrhagic complications, so immediate treatment is required, and protamine sulfate may be used as an antidote, but it also carries risks of side effects, so caution is warranted. While under treatment, avoid intramuscular injections, and do not mix this medication with antihistamines for injection.

Serious side effects

Urticaria, angioedema, chest tightness, shortness of breath, shock, thrombocytopenia, heparin-induced thrombocytopenia (HIT), thrombosis due to thrombocytopenia, bleeding (gastrointestinal bleeding, intracranial bleeding, ovarian bleeding, retroperitoneal bleeding, intracranial bleeding), severe skin rash or blistering with high fever, skin peeling, mucosal pain in the mouth/eyes, liver abnormality (including jaundice), severe symptoms due to hyperkalemia, severe headache, seizures.

Mild side effects

Itching, chills, fever, rhinitis, tearing, conjunctivitis, tachycardia, pressure sensation, nausea, vomiting, hypotension, bronchospasm, hair loss, leucopenia, hemorrhagic necrosis, hypoaldosteronism, osteoporosis, rebound effect, dyslipidemia, renal suppression, local pain or hematoma due to subcutaneous or intramuscular injection, priapism, diabetes, hyperkalemia, metabolic acidosis, elevated lipase, erythema, mild pain, ulcer, chills, fever.

This medication is sensitive to light, so it should be stored in a container that does not allow light to pass through. Also, it is best to store it at room temperature between 1 and 30 degrees Celsius. This will help maintain the effectiveness of the medication.

Appearance

A clear solution that is colorless to pale yellow contained in a brown vial.

Package unit

5 mL/vial x 10, 20 mL/vial x 10