Clarik Tablets 250 mg (Clarithromycin)

Adult dose

Adults: The usual dose is 250mg (potency) of clarithromycin twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or 250mg (potency) twice daily for severe infections. Do not administer this drug to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this drug twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this drug 3 times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children 12 years of age and older: same as adults For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in patients who are allergic to certain components or have had hypersensitivity reactions to macrolide antibiotics. Caution should be taken when used with medications that may affect heart rhythms as it can increase the risk of cardiac arrhythmias. In patients with severely impaired liver or kidney function, the use of this medication may be limited or require dose adjustment. It is safe for pregnant or breastfeeding women to avoid this medication, and if it must be taken, consulting a specialist is necessary. This medication may interact with various drugs; therefore, it is essential to inform healthcare providers of any medications currently being taken. If any unusual symptoms such as allergic reactions, severe skin rashes, difficulty breathing, chest pain, severe abdominal pain, persistent diarrhea appear during the course of this medication, it should be discontinued immediately, and healthcare providers should be consulted. Elderly patients or those with heart disease require special caution when taking this medication, and regular monitoring is recommended. When used for prolonged or repeated periods, resistant bacteria may develop; therefore, adherence to the duration and dose prescribed by the physician is crucial. Caution is advised during driving or operating machinery, as dizziness or confusion may occur. It is also advisable to periodically check electrolyte and blood sugar levels for conditions such as hypokalemia or hypoglycemia during treatment.

Shock, anaphylactic symptoms, respiratory distress, convulsions, flushing, rash, itching, hives, mild skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, epigastric pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, stool discoloration, membranous colitis, hemorrhagic colitis, fever, cough, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, taste loss, smell loss, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, increased ALP, increased total bilirubin, anorexia, jaundice, dark urine, pruritus, abdominal tenderness, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, fatigue, elevated CPK, increased serum myoglobin, increased urinary myoglobin, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, dysgeusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, auditory dysfunction, hypoglycemia, purpuric rash, acute generalized exanthematous pustulosis, muscle spasms, musculoskeletal rigidity, myopathy, elevated blood urea, nephritis, injection site vein inflammation, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, vesicular dermatitis, sweating, papular rash, acne, Henoch-Schonlein purpura, acute pancreatitis, cardiac arrest, atrial fibrillation, ECG QT prolongation, premature contractions, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, movement disorders, non-vestibular dizziness, drowsiness, tremor, loss of consciousness

This medication should be stored in a tightly closed container to avoid exposure to air or moisture. Additionally, it is best to store the medication at room temperature between 1°C and 30°C.

Appearance

Yellow oblong film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle