Sputam Injection 10% (Acetylcysteine)

Adult administration

1. Mucolytic Action 1) Intravenous Injection For adults, acetylcysteine should be administered intravenously at a dose of 600 to 900 mg once, 2 to 3 times a day. 2) Intramuscular Injection For adults, this medication should be administered intramuscularly at a dose of 300 mg once, 1 to 2 times a day. 2. Detoxification of Acetaminophen Overdose Dilute 150 mg per kg body weight in 200 mL of 5% dextrose solution for intravenous drip within the first 15 minutes. After that, dilute 50 mg per kg body weight in 500 mL of 5% dextrose solution.

Child administration

1. Mucolytic Action 1) Intravenous Injection For children, this medication should be administered intravenously at a dose of 300 to 450 mg once, 2 to 3 times a day. 2) Intramuscular Injection For children, this medication should be administered intramuscularly at a dose of 150 mg once, 1 to 2 times a day.

This medication is in a glass ampoule injection form, and caution should be taken when opening the container, as glass fragments may mix with the solution. Extra care is particularly required when used in children or the elderly. This medication should not be used by individuals who are allergic to it or its components. Patients with bronchial asthma or poor respiratory function should be cautious, as this medication may cause bronchospasm; if abnormal symptoms occur, administration should be stopped immediately and appropriate treatment should be obtained. It is preferable not to use this medication in neonates unless it is a severe condition. Occasionally, gastrointestinal symptoms such as nausea, vomiting, decreased appetite, and diarrhea may occur with this medication. Rarely, hypersensitive reactions such as urticaria, itching, rash, headache, tinnitus, and bronchospasm may occur. Additionally, there may be rare instances of increased heart rate or elevated blood pressure, and very rarely a severe allergic reaction known as anaphylaxis may occur. When used as an antidote, administering large doses intravenously may cause symptoms similar to hypersensitivity and severe hypertension, so caution is necessary and administration should be stopped immediately if abnormal symptoms arise. While using this medication, bronchial secretions may increase; therefore, careful monitoring of the patient's condition is essential, and appropriate measures such as mechanical suction or positional changes should be taken as needed. For intramuscular injection, deep injection is recommended. When used as an antidote, it is effective if administered within 10 hours after poisoning. This medication may interact chemically with certain drugs, so caution should be exercised when mixing or administering with other medications. There is insufficient research on the safety of this medication during pregnancy, so it should only be used when necessary. Nursing women should also use this medication with caution, as it is unclear whether it passes into breast milk. Elderly patients may have diminished bodily functions, so careful monitoring and cautious administration are advised.

Serious side effects

• Urticaria
• bronchospasm
• anaphylaxis
• respiratory distress
• angioedema

Mild side effects

• Nausea
• vomiting
• decreased appetite
• diarrhea
• itching
• rash
• headache
• tinnitus
• tachycardia
• hypertension

This medication may be sensitive to light and should be stored in a container that does not allow light penetration. Additionally, it is important to store the medication at room temperature, maintaining a temperature between 1 degree and 30 degrees Celsius. This will help maintain the effectiveness of the medication.

Appearance

A brown ampoule filled with a colorless to pale purple transparent liquid.

Package unit

10 ampoules/box [3 ml/ampoule x 10 units], 10 ampoules/box [6 ml/ampoule x 10 units]