Amaryl Tablets 4 mg (Glimepiride)

Adult dose

Adjusted individually for each patient. Administered orally once daily, swallowed whole without chewing with more than 1/2 cup of water. It should be taken before breakfast or just prior to the first meal, and it is important not to skip meals after taking this medication. The initial dose for monotherapy is started at 1 mg of glimepiride once daily, with increments of 1 mg every 1 to 2 weeks. Generally, there is little additional benefit when doses exceed 4 mg.

This medication should not be used in patients with insulin-dependent Type 1 diabetes, diabetic ketoacidosis, or those in a coma. It is also advisable not to administer this medication to patients who are allergic to this drug or its ingredients, or who have severe liver or kidney dysfunction. It is safest for pregnant women or women who may become pregnant, as well as nursing mothers, to avoid this medication and consider insulin treatment instead. Insulin therapy is recommended for patients with severe infections, pre- and post-surgical conditions, or severe trauma. Caution is advised for patients with gastrointestinal disturbances, as this may inhibit food absorption and increase the risk of hypoglycemia. Patients with lactose intolerance or specific genetic metabolic disorders should not take this medication. In the early stages of treatment, there is a higher risk of hypoglycemia, so close monitoring of blood sugar levels is essential. Elderly patients, those with poor nutritional status or irregular eating patterns, patients with impaired kidney or liver function, and individuals who consume alcohol frequently are at higher risk for hypoglycemia. Patients with thyroid or adrenal dysfunction should also be cautious. Symptoms of hypoglycemia may include headaches, severe hunger, vomiting, fatigue, anxiety, confusion, drowsiness, and decreased consciousness; if these symptoms appear, immediate consumption of sugar is necessary. This medication may interact with various drugs that can affect blood sugar control, so it is important to inform healthcare providers if taking other medications, especially beta-blockers, some antibiotics, anti-inflammatory drugs, or steroids. Pregnant or nursing women are advised to consider insulin treatment due to potential effects on the fetus and newborn. The safety and efficacy of this medication have not been established in children under 18 years of age. The elderly may require dose adjustments due to decreased kidney function slowing drug elimination. In cases of overdose, severe hypoglycemia may occur, warranting immediate medical attention for appropriate emergency treatment. This medication should be stored out of reach of children and kept securely sealed in its original container.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash accompanied by fever, blisters, skin peeling, mucous membrane pain in the mouth/eyes, respiratory distress, asthma attacks, coughing with fever and respiratory issues, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headaches, migraine-like headaches, seizures, confusion, vision changes, paralysis, markedly decreased urine output.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep problems
• anxiety
• aggression
• reduced concentration
• decreased activity

This medication must be stored in a tightly sealed container to prevent exposure to air or moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius at room temperature. This practice helps preserve the medication's effectiveness and safety.

Appearance

Light blue rectangular tablets.

Package unit

30 tablets (10 tablets/PTP X 3). 100 tablets/bottle