Estrebagel (estradiol hemihydrate)

Key information summary

Efficacy & effects

This medication is used to relieve symptoms of estrogen deficiency caused by natural or surgical menopause. Specifically, it improves symptoms such as hot flashes, sleep disturbances, emotional instability, and atrophy of the urogenital tract. It also helps prevent bone tissue loss that may occur after menopause, thereby hindering the progression of osteoporosis. It is available in tablet, gel, and transdermal form, allowing for selection based on the patient's condition and preference. It is used to effectively treat various menopause-related symptoms and complications.

Dosage

(Tablet) Administer orally as estradiol, once daily, either 1 or 2 mg without interruption. (Gel) The individual dosage is 0.75 mg of estradiol (gel volume of 1.25 g), with an average of 1.5 mg of estradiol administered daily (twice the dosage) for 24 to 28 days in a month. (Gel 1 mg/g) Estradiol, 0.5 to 1.5 mg daily (gel volume of 0.5 to 1.5

Precautions

This medication may increase the risk of endometrial thickening or endometrial cancer in postmenopausal women. Women who have not had a hysterectomy are advised to take progestin as directed by a doctor while using this medication. Regular examinations are required for long-term use. Using this medication for more than 5 years may slightly increase the risk of breast cancer, necessitating regular breast examinations and self-checks. In patients with breast cancer or bone metastasis, this medication may cause hypercalcemia, requiring cessation and appropriate treatment. It should not be used in patients with breast cancer, endometrial cancer, liver disease, thrombosis, cardiovascular disease, cerebrovascular disease, pregnant women or women of childbearing potential, and nursing mothers. It should be used cautiously in patients with certain conditions or a history of such conditions, including smooth muscle tumors, endometriosis, hypertension, diabetes, liver disease, migraines, and asthma, with regular examinations needed before and after treatment. During the use of this medication, any unusual bleeding, jaundice, increased blood pressure, headaches, or visual disturbances should be reported to a doctor immediately. Additionally, it can be temporarily discontinued before and after surgery to reduce the risk of thrombosis. This medication may interact with certain drugs, so inform the healthcare provider about any other medications being taken. Women who are pregnant or planning to become pregnant should not use this medication, and it should be stopped immediately if pregnancy is confirmed during use. It is also recommended that nursing women do not use this medication. In cases of overdose, symptoms such as nausea, vomiting, and breast tension may occur, and no specific antidote is available; treatment should be based on symptoms. This medication should be kept out of the reach of children, stored in its original container, and maintained at room temperature below 25 degrees Celsius. Regular health check-ups and strict adherence to the doctor's instructions during the use of this medication are vital.

Side effects

Urticaria, venous thrombosis, myocardial infarction, pulmonary embolism, angioedema, anaphylactic reactions, significant increases in blood pressure, cholestatic jaundice, liver dysfunction, thromboembolism, deep vein thrombosis, stroke, vascular eye diseases, heart failure, hypercalcemia, endometrial cancer, breast cancer, endometrial hyperplasia, cerebrovascular or coronary artery diseases, stroke, severe edema, acute arterial thromboembolism, angina, heart diseases, dementia,

Alternatives / Same-ingredient medications

• Dibi Gel 0.1% gel (estradiol)

  Same ingredient
• 

  Preda Tablet 1mg (Estradiol Monohydrate)

  Same ingredient

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