Surozine (Roxithromycin)

Adult dose

Adults: Administer 150㎎ (potency) of roxithromycin orally twice daily, in the morning and evening before meals. For pneumonia, administer 300mg (potency) once daily before breakfast. Adjust the dose as appropriate according to age and symptoms.

Child dose

Children: The mean dose used in clinical trials was 6mg (potency) per kg of body weight per day. Administer 5～8mg (potency) per kg of body weight per day orally in 2 divided doses. The dose according to body weight is as follows. Children weighing 6～11Kg: Take 25mg (potency) per dose twice daily before meals (for pediatric tablets and granules only); take 2.5mL per dose twice daily before meals (for suspension only). Children weighing 12～23Kg: Take 50mg (potency) per dose twice daily before meals (for pediatric tablets and granules only); take 5mL per dose twice daily before meals (for suspension only). Children weighing 24～40Kg: Take 100mg (potency) per dose twice daily before meals (for pediatric tablets and granules only); take 10mL per dose twice daily before meals (for suspension only).

This medication can rarely cause serious skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and acute generalized exanthematous pustulosis. If signs of progressive skin rash develop, such as blistering or mucosal damage, discontinue use immediately. Patients allergic to antibiotics in the same class or those taking certain medications (terfenadine, astemizole, cisapride, pimodivir) should not use this medication. Moreover, patients taking ergot alkaloids should avoid this medication as it may cause side effects like peripheral vascular spasms or numbness in the extremities. This medication should be used cautiously in patients with impaired liver function or the elderly, and care should be taken to avoid antibiotic resistance when used with other specific antibiotics. This medication can affect heartbeat; patients with congenital heart rhythm disorders or those taking specific antiarrhythmics should be especially careful. Patients with myasthenia gravis should be cautious as symptoms can worsen when taking this medication. An allergic shock may rarely occur, so if unusual symptoms arise, discontinue use immediately and seek appropriate treatment. Gastrointestinal side effects may include loss of appetite, nausea, diarrhea, etc., and if severe abdominal pain or frequent diarrhea occurs, discontinue use immediately. If severe diarrhea or bleeding ensues during use, it may indicate pseudomembranous colitis, necessitating immediate consultation with medical personnel. If symptoms such as difficulty breathing, coughing, or fever appear, there may be a possibility of pneumonia, so discontinue treatment and seek care. This medication can cause various side effects including drowsiness, dizziness, taste and smell disturbances, skin rash, etc. Long-term use should be monitored closely to prevent the emergence of resistant bacteria and co-infections. Women who are pregnant or may become pregnant should consult medical personnel before using this medication, and nursing mothers should either avoid use or discontinue breastfeeding. Dizziness and visual disturbances may occur, so caution is needed when driving or operating machinery. This medication should be kept out of reach of children, and it is safe not to transfer to other containers.

Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, shock, anaphylactic shock, fever, rash, allergic skin reaction, angioedema, eosinophilia, agranulocytosis, leukopenia, thrombocytopenia, cholestatic acute hepatitis, hepatic cellular acute hepatitis, jaundice, elevated AST, elevated ALT, elevated ALP, elevated serum bilirubin, loss of appetite, nausea, vomiting, abdominal discomfort, dyspepsia, abdominal pain, abdominal distension, diarrhea, pseudomembranous colitis, loose stools, hemorrhagic colitis, blood in stool, pancreatitis, bronchospasm, cough, dyspnea, abnormal chest X-ray, interstitial pneumonia, drowsiness, headache, dizziness, tongue paralysis, paralysis, taste disorder, ageusia, olfactory disorder, loss of smell, erythema multiforme, purpura, superinfection due to overgrowth of non-susceptible pathogens, transient hearing loss, auditory impairment, visual disturbance, blurred vision, conjunctival injection, general malaise, weakness, palpitations, QT prolongation, ventricular tachycardia, arthralgia, epistaxis, menstrual irregularities, inflammation of oral and vaginal mucosa, hallucination, confusion

This medication should be stored in a tightly closed container to prevent exposure to air and moisture, and it is best kept at room temperature, specifically between 1 and 30 degrees Celsius.

Appearance

White round tablets

Package unit

30 tablets/bottle, 100 tablets/bottle