Vancomycin 250 mg Capsules (Vancomycin Hydrochloride)

Adult dosage

(Capsules) 500 mg (equivalent) of vancomycin per day, divided for oral administration for 7-10 days. In severe cases, 2 g (equivalent) divided into 3-4 doses per day may be used, with a total daily dose not exceeding 2 g. (Injectable) 500 mg (equivalent) intravenously every 6 hours, or 1 g (equivalent) intravenously every 12 hours. Generally, the oral dose should be divided into 500-2000 mg per day for 3-4 doses.

Children's dosage

(Capsules) 40 mg (equivalent) per day per kg of body weight, divided into 3–4 doses for 7–10 days. The total daily dose must not exceed 2 g, and should be adjusted appropriately based on age and symptoms. (Injectable)

This drug should not be administered to specific patients. For example, patients who have had allergic reactions to this drug or its components, those with lactose intolerance or genetic lactose metabolism disorders should not use this medication. Certain patients require caution when using this drug. Patients with allergies to peptide or aminoglycoside antibiotics, those with a history of hearing loss, patients with kidney function problems, the elderly, and those allergic to specific dyes should use this drug carefully. During the administration of this drug, serious side effects may occur, so careful monitoring is necessary. For instance, symptoms such as hypotension or dizziness, blood cell count reduction, hearing loss, worsening kidney function, skin rashes, or severe skin reactions have been reported. If such symptoms occur, the medication should be discontinued immediately and appropriate treatment must be sought. To prevent the emergence of resistant bacteria, it is advisable to perform sensitivity tests and use this medication only for the necessary minimum duration. Additionally, repeated oral administration of this drug may lead to severe intestinal diseases such as pseudomembranous colitis; therefore, caution is advised. Due to the risk of auditory toxicity, especially for patients who already have hearing loss or are taking ototoxic medications, regular hearing checks are necessary. Patients with impaired kidney function or those using aminoglycosides should have their kidney function closely monitored. Long-term use of this drug may lead to overgrowth of non-sensitive bacteria, so administration should be stopped if symptoms of dysbiosis occur. Severe skin reactions may occur, therefore if symptoms such as rashes, blisters, or mucosal damage develop, drug usage should be stopped immediately. If diarrhea symptoms appear following antibiotic use, the possibility of Clostridium difficile infection should be suspected, and appropriate treatment should be sought in this case. This medication may affect blood coagulation; therefore, patients taking anticoagulants such as warfarin must frequently check their status with blood tests and adjust the drug dosage if necessary. Women who are pregnant or breastfeeding should use this medication cautiously since its safety has not been definitively established. Since this drug can be transmitted through breast milk and affect the infant, caution is needed during breastfeeding. Elderly patients require special caution during administration due to physiological changes like reduced kidney function, which can increase the risk of drug accumulation in the body. In the case of overdose, kidney function supportive treatment is necessary, and this medication is not easily removed by standard dialysis; specialized treatment is required. This drug works by interfering with the synthesis of bacterial cell walls, and resistance has been reported in some bacteria, so this should be considered during treatment.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor (shock symptoms), severe allergic reactions, high fever accompanied by severe rash, blisters, skin peeling, mouth/eye mucosal pain (including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash), severe skin reactions, shortness of breath or breathing difficulties, asthma attacks, respiratory issues accompanied by cough + fever (including wheezing, dyspnea)

Mild side effects

Oral abnormalities, dizziness, changes in stool, tinnitus, sweating, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytopenia, liver dysfunction, stomatitis, glossitis, hypotension, drug-induced fever, flushing, nausea, loss of appetite, chills, cold sensation, itching, exfoliative dermatitis, muscle cramps in the chest and back, upper body flushing, rash, hives, elevated serum creatinine or BUN levels, azotemia, hearing loss (due to overdose, history of hearing loss)

This drug should be stored in a tightly sealed container to prevent moisture and air ingress. It is advisable to maintain a storage temperature between 1 and 30 degrees Celsius to preserve the drug's efficacy and safety.

Appearance

Capsule filled with light brown powder, dark brown upper part, and dark purple lower part.

Package unit

For domestic use - 30 capsules/bottle, for export - 50 capsules/bottle, for export - 30 capsules/bottle, for export - 30 capsules/PTP [30 capsules (10 capsules/PTP x 3)], for export - 40 capsules/PTP [40 capsules (10 capsules/PTP x 4)]