Heriklo Tablets 250 mg (Clarithromycin)

Adult dose

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this drug to such patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this drug twice daily. In this case, it should be administered concomitantly with other antimycobacterial agents, such as ethambutol, clofazimine, or rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this drug 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1～14) and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children aged 12 years and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in certain patients. For example, individuals with allergies to any ingredient in this medication or who have had hypersensitivity reactions to similar classes of antibiotics should not be administered this drug. Additionally, patients with specific heart conditions or severely impaired liver or kidney function should also avoid its use. It is also advised that pregnant or breastfeeding women do not take this medication. When using this medication, special caution should be exercised in patients with weak liver or kidney function, the elderly, and those with heart diseases. Care should also be taken when taken alongside other antibiotics, and patients with allergy histories should be extra careful. This drug can cause various side effects, so if symptoms such as difficulty breathing, rash, severe abdominal pain, diarrhea, hearing impairment, or cardiac symptoms appear during use, discontinue use immediately and inform a doctor. Particularly, there is a risk of severe allergic reactions, liver or kidney dysfunction, and arrhythmias; thus, prompt treatment is essential if symptoms arise. This medication may interact with other drugs, so it is crucial to inform healthcare providers of any currently taken medications. Care is especially needed when used with heart-related medications, drugs that affect liver metabolism, glucose-lowering medications, anticoagulants, etc. Women who are pregnant or breastfeeding should not take this medication, and if they must, it is recommended to discontinue breastfeeding. The safety and efficacy of this medication have not been thoroughly studied in children, thus its use is not recommended in children under the age of 12. Elderly individuals may have impaired kidney function, thus dose adjustment may be necessary, and careful monitoring is essential. Long-term or high-dose use of this medication may lead to hearing impairment or tinnitus; therefore, consultation with healthcare providers is recommended if symptoms develop. In cases of overdose, gastrointestinal disturbances or central nervous system symptoms may occur, necessitating immediate medical attention for appropriate treatment. This medication should be stored away from direct sunlight in an opaque container and should not be refrigerated.

Shock, anaphylactic symptoms, respiratory distress, convulsions, flushing, rash, itching, hives, skin erythema, angioedema, joint swelling, drug rash, abdominal bloating, nausea, vomiting, indigestion, abdominal pain, malaise, gas retention, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, loss of appetite, constipation, stool discoloration, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, increased AST, increased ALT, increased γ-GTP, increased LDH, increased ALP, increased total bilirubin, increased serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, dysgeusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, auditory impairment, hypoglycemia, purpuric rash, acute general pustular psoriasis, muscle cramps, musculoskeletal rigidity, myopathy, increased blood urea nitrogen, nephritis, phlebitis at injection site, pain at injection site, inflammation at injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This medication is sensitive to light, so it should be stored in a container that protects it from light. Additionally, it is important to store the medication at room temperature between 15 to 30 degrees Celsius for safety.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle