Surid Tablet (Roxithromycin)

Adult dose

Adults: Administer roxithromycin 150㎎ (potency) per dose orally twice daily, before breakfast and dinner. For pneumonia, administer 300mg (potency) once daily before breakfast. The dose may be adjusted as appropriate according to age and symptoms.

Child dose

Children: The average dose used in clinical trials was 6mg (potency) per kg of body weight daily. Administer this medicine orally in 2 divided doses of 5～8mg (potency) per kg of body weight daily. For children weighing 6～11Kg: Take 25mg (potency) per dose twice daily before meals (for pediatric tablets and granules only); take 2.5mL per dose twice daily before meals (for suspension only). For children weighing 12～23Kg: Take 50mg (potency) per dose twice daily before meals (for pediatric tablets and granules only); take 5mL per dose twice daily before meals (for suspension only). For children weighing 24～40Kg: Take 100mg (potency) per dose twice daily before meals (for pediatric tablets and granules only); take 10mL per dose twice daily before meals (for suspension only).

This medication can rarely cause serious skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, or acute generalized exanthematous pustulosis, so if there are signs of blisters or mucosal damage, treatment should be stopped immediately. This drug should not be administered to patients with hypersensitivity to macrolide antibiotics or those taking certain medications (terfenadine, astemizole, cisapride, pimodidine, ergot alkaloids, mizolastine). Caution should be exercised when administering to patients with impaired liver function or the elderly, and it should be used cautiously in combination with other antibiotics due to an increased risk of resistance or adverse effects. It may cause cardiovascular problems, thus it should be used with caution in patients with prolonged QT interval or at risk of arrhythmia. Myasthenia gravis patients should be monitored closely, as this drug may exacerbate symptoms. This drug can cause various side effects such as allergic reactions, blood disorders, hepatitis, gastrointestinal disturbances, severe diarrhea, pneumonia, neurological abnormalities, taste and smell disturbances, and skin rashes; if any abnormal symptoms occur, consult a healthcare professional immediately. Prolonged use may increase the risk of infections due to overgrowth of resistant organisms, so continuous monitoring of the condition is necessary. This drug can increase serum concentrations of other drugs metabolized in the liver, and it can cause cardiac abnormalities or toxic symptoms when combined with certain medications, hence patients should inform healthcare providers of any medications they are taking. Women who are pregnant or potentially pregnant should carefully assess whether the benefits outweigh the risks when using this drug, as it may affect the fetus. For breastfeeding women, it is advisable to either discontinue nursing or avoid the use of this medication, as it is minimally excreted in breast milk. Elderly patients do not require special dosage adjustments, but should be closely monitored for adverse effects upon administration. Dizziness or blurred vision may occur; caution is advised during machine operation or driving. Lastly, this medication should be kept out of reach of children and should not be transferred to another container as it may compromise quality and safety.

Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, shock, anaphylactic shock, fever, rash, allergic skin reactions, angioedema, eosinophilia, agranulocytosis, leukopenia, thrombocytopenia, cholestatic acute hepatitis, hepatocellular acute hepatitis, jaundice, elevated AST, elevated ALT, elevated ALP, elevated serum bilirubin, loss of appetite, nausea, vomiting, upper abdominal discomfort, abdominal pain, abdominal distension, diarrhea, pseudomembranous colitis, loose stools, hemorrhagic colitis, bloody stools, pancreatitis, bronchospasm, cough, dyspnea, abnormal chest X-ray, interstitial pneumonia, drowsiness, headache, dizziness, tongue paralysis, paralysis, dysgeusia, ageusia, dysosmia, anosmia, erythema multiforme, purpura, secondary infection due to the overgrowth of non-susceptible pathogens, temporary hearing loss, hearing impairment, visual disturbances, blurred vision, conjunctival injection, generalized malaise, weakness, palpitations, QT prolongation, ventricular tachycardia, arthralgia, epistaxis, menstrual irregularities, inflammation of the oral and vaginal mucosa, hallucinations, confusion

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is recommended to maintain storage temperature between 1 and 30 degrees Celsius.

Appearance

White round sugar-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle