Rodepin Tablet 25 mg (Jotepin)

Adult dose

The therapeutic dose of this medicine should be adjusted according to the patient's clinical condition, and the lowest effective dose possible should be administered. ○ Adults: Administer zotepine 75∼150 mg per day orally in divided doses. The dose may be increased up to 450 mg per day depending on symptoms. If the daily dose is 300 mg or more, administer doses at intervals of at least 4 hours.

This medicine may increase the mortality rate when treating psychiatric symptoms in elderly dementia patients, so special caution is required. When used in patients with cerebrovascular disease, there may be an increased risk of stroke, so it should be administered carefully. There is a risk of venous thromboembolism, so risk factors for thrombosis should be checked and preventive measures taken before and during administration. Do not administer to patients in a comatose state or circulatory collapse, those taking central nervous system depressants, patients receiving epinephrine, those allergic to this medicine or similar medications, patients with acute alcohol intoxication, patients with hematopoietic dysfunction, pregnant and nursing women, children, and patients taking certain medications. Exercise caution in patients with brain disorders, liver dysfunction, blood disorders, heart diseases, respiratory diseases, seizure disorders, the elderly, and those in a hot environment, as well as in cases of hypertension, renal failure, urinary disorders, and malnutrition. This medicine can cause serious side effects such as neuroleptic malignant syndrome, arrhythmias, paralytic ileus, seizures, and tardive dyskinesia, so if any unusual symptoms occur, discontinue use immediately and seek appropriate treatment. Drowsiness, decreased attention, and concentration may occur, and it is advisable to avoid driving or operating hazardous machinery, as symptoms may be exacerbated when taken with alcohol. Blood disorders such as leukopenia may occur, so regular blood tests should be conducted, and if abnormalities are found, use should be discontinued. This medicine may interact with various drugs, so consult a physician or pharmacist before taking other medications. Pregnant women or women who may become pregnant and nursing mothers should not take this medicine. If nursing, either stop breastfeeding or discontinue the medication. Safety in children has not been established, so it should not be administered to children. In case of an overdose, severe symptoms such as central nervous system depression, low blood pressure, and seizures may occur, so immediate medical treatment is necessary. Keep out of reach of children, do not transfer to another container, and be cautious as unexplained sudden deaths have been reported during treatment.

Increased mortality rate, increased risk of cerebrovascular disease, venous thrombosis, worsening of comatose state, hypersensitivity reactions, hyperthermia reactions, worsening of liver dysfunction, worsening of blood disorders, rapid blood pressure fluctuations, respiratory depression, seizures, neuroleptic malignant syndrome, akinesia, severe muscle rigidity, dysphagia, tachycardia, blood pressure fluctuations, sweating, persistent fever, leukocytosis, elevated serum creatine phosphokinase, myoglobinuria, renal impairment, altered consciousness, dyspnea, circulatory collapse, dehydration symptoms, acute renal failure, electrocardiogram changes, intestinal paralysis, loss of appetite, nausea, vomiting, significant constipation, abdominal distension, convulsive seizures, involuntary movements around the mouth, hyponatremia, hypotonic hyponatremia, increased sodium excretion in urine, hyperosmolar urine, conduction disturbance, orthostatic regulation disorder, hypotension, arrhythmia, dyspnea, thromboembolism, constipation, diarrhea, stomatitis, increased appetite, abdominal discomfort, cholestasis, Parkinson's syndrome, tremor, flexibility, muscle rigidity, decreased activity, gait disturbance, facial rigidity, mask-like facies, dyskinesia, dysarthria, ocular rotation seizures, abnormal posture, inability to sit still, drowsiness, abnormal brain waves, nonsensical speech, depression, insomnia, anxiety, agitation, restlessness, excitability, easy to provoke, hypersexuality, increased talkativeness, exhaustion, posterior neck swelling, asthma, visual accommodation disturbance, sweat gland secretion disorder, weakness, fatigue, malaise, thirst, dizziness, headache, heaviness in the head, nasal congestion, urination difficulties, paresthesia, incontinence, sweating, frequent urination, increased salivation, carbohydrate metabolism disorder, sexual dysfunction, menstrual irregularities, galactorrhea, corneal opacity, lens opacity, accommodation disorder, glaucoma, facial flushing, photosensitivity reaction, edema, rash, skin itching, drug reaction (DRESS), agranulocytosis, decreased serum uric acid, systemic lupus erythematosus-like symptoms, visual impairment, fever, taste distortion, weight gain, weight loss, pupil dilation, drowsiness, central nervous system depression, hypotension, extrapyramidal symptoms, intense emotions, emotional instability

This medicine should be stored in a sealed container to protect it from air and moisture exposure. It is advisable to maintain storage temperature at room temperature, i.e., a general environment that is not too hot or cold.

Appearance

This medicine is a lavender-colored film-coated tablet.

Package unit

30 tablets/bottle, 500 tablets/bottle