Lopesin Tablet (Roxithromycin)

Adult dose

Adults: Administer 150 mg (potency) of roxithromycin orally per dose twice daily, before breakfast and dinner. For pneumonia, administer 300 mg (potency) once daily before breakfast. Adjust the dose appropriately according to age and symptoms.

Child dose

Children: The average dose used in clinical trials was 6 mg (potency) per kg of body weight per day. Administer 5–8 mg (potency) per kg of body weight per day orally in 2 divided doses. The doses by body weight are as follows: - Children usually weighing 6–11 kg: Take 25 mg (potency) per dose twice daily before meals (pediatric tablets and granules only), or take 2.5 mL per dose twice daily before meals (suspension only). - Children weighing 12–23 kg: Take 50 mg (potency) per dose twice daily before meals (pediatric tablets and granules only), or take 5 mL per dose twice daily before meals (suspension only). - Children weighing 24–40 kg: Take 100 mg (potency) per dose twice daily before meals (pediatric tablets and granules only), or take 10 mL per dose twice daily before meals (suspension only).

This medication may rarely cause serious skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and acute generalized exanthematous pustulosis. If any progressive skin rash symptoms appear, such as blistering or damage to mucous membranes, discontinue use immediately. This medication should not be used in patients with hypersensitivity to macrolide antibiotics or those taking certain medications. Specifically, it should not be administered to those taking terfenadine, astemizole, cisapride, pimodidine, ergot alkaloids, or mizolastine. Caution should also be exercised when used in patients with impaired liver function or the elderly, and resistance issues should be monitored when used in combination with other antibiotics. Additionally, this medication can affect the heart's electrical signals, so caution is needed for patients with congenital heart disease or a risk of arrhythmias. Patients with myasthenia gravis may experience worsening symptoms, so special care is needed. This medication can cause various side effects including allergic reactions, blood abnormalities, liver dysfunction, gastrointestinal disturbances, serious colitis, respiratory issues, neurological symptoms, sensory disturbances, and skin rashes. If abdominal pain or diarrhea worsens, discontinue use immediately and consult healthcare professionals. This medication should not be used in combination with certain drugs, as it may interfere with the metabolism of other drugs in the liver, increasing blood concentrations and potentially causing serious side effects such as cardiac arrhythmias. Extra caution is needed when used with anticoagulants such as warfarin, as the risk of bleeding may increase. Women who are pregnant, or may become pregnant, should consult a healthcare provider before using this medication, as it may affect the fetus. When breastfeeding, this medication may transfer in small amounts into breast milk, so it is advisable to avoid use or discontinue breastfeeding if possible. The half-life of this medication may be prolonged in the elderly, but general dosage adjustments are not usually necessary. Symptoms such as dizziness or blurred vision may occur during treatment, so caution is needed when operating machinery or driving. Finally, this medication should be kept out of reach of children and should not be transferred to another container.

Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, shock, anaphylactic shock, fever, rash, allergic skin reactions, angioedema, eosinophilia, agranulocytosis, leukopenia, thrombocytopenia, cholestatic acute hepatitis, hepatocellular acute hepatitis, jaundice, elevated AST, elevated ALT, elevated ALP, elevated serum bilirubin, loss of appetite, nausea, vomiting, discomfort in the upper abdomen, dyspepsia, abdominal pain, abdominal distension, diarrhea, hemorrhagic colitis, bloody stools, pseudomembranous colitis, bronchospasm, cough, dyspnea, abnormal chest X-ray, interstitial pneumonia, drowsiness, headache, dizziness, tongue paralysis, paralysis, taste disorder, ageusia, olfactory disorder, anosmia, erythema multiforme, purpura, secondary infections due to supergrowth of non-susceptible pathogens, transient hearing loss, auditory impairment, visual disturbances, blurred vision, conjunctival injection, general malaise, weakness, palpitations, QT prolongation, ventricular tachycardia, arthralgia, epistaxis, menstrual irregularities, inflammation of oral and vaginal mucosa, hallucinations, confusion

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is best stored at room temperature, not too hot or too cold.

Appearance

Biconvex white round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle