Moxicle 375 mg (Amoxicillin and Clavulanate Potassium)

Adult dose

For adults and children aged 12 years or older or weighing 40 kg or more, administer 250 mg/125 mg of amoxicillin/clavulanate potassium orally three times a day every 8 hours. In cases of severe and respiratory infections, the dose may be increased to 500 mg/125 mg. In cases of renal impairment, adjustments should be made according to creatinine clearance. For a creatinine clearance of 10 to 30 mL/min, administer 250 to 500 mg.

Child dose

For children under 12 years of age or weighing less than 40 kg, administer with dosage reduction by the same method.

This drug is a beta-lactam antibiotic and should not be used in patients with a history of hypersensitivity to penicillins or cephalosporins. Caution is needed for patients with infectious mononucleosis or lymphocytic leukemia due to a higher risk of rash. It is best not to use this medication in patients with a history of liver dysfunction or jaundice. For patients with liver disease or severe renal impairment, careful dosing should be considered as the drug concentration may increase, necessitating adjustments in administration intervals. Patients with allergic constitutions, those who have difficulty with oral intake, elderly patients, or those in poor general condition may experience vitamin K deficiency, requiring caution. Patients with gastrointestinal diseases or severe vomiting and diarrhea may not absorb the drug adequately. If symptoms like diarrhea, abdominal pain, or blood in stools occur, the medication should be stopped immediately, and a doctor should be consulted. Signs of liver dysfunction may appear during or after discontinuation of treatment, necessitating liver function tests, and regular monitoring of liver and kidney functions is recommended for prolonged therapy. Adverse reactions such as skin rashes, hives, and in severe cases, anaphylactic shock may occur; if these symptoms arise, drug administration should be stopped immediately, and emergency care sought. Various adverse effects, including blood disorders, central nervous system symptoms, and renal function abnormalities, have been reported, so patient conditions must be closely monitored. Pregnant women in early pregnancy or breastfeeding should use this drug with caution, and those who are breastfeeding may observe diarrhea or skin rashes in their infants. It is not recommended for children under 12 years of age or those weighing less than 40 kg. The elderly experience a heightened risk of adverse effects due to decreased physiological function, thus should be carefully dosed with adjusted intervals. This drug may interact with others; therefore, consultation with a doctor or pharmacist is necessary when taking with anticoagulants, antibiotics, or anti-inflammatory drugs. In cases of overdose, gastrointestinal symptoms, renal failure, or seizures may occur, warranting immediate cessation of the drug and appropriate medical treatment. This medicine should be stored below 25 degrees Celsius in a dry place, and past allergic reactions must always be verified before use.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe rash with high fever, blisters, skin peeling, oral/ocular mucosal pain, shortness of breath or difficulty breathing, asthmatic attacks, respiratory anomalies with cough and fever, skin or eyes turning yellow (jaundice), pronounced lethargy, sudden and severe headaches, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urination issues

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain

This drug should be stored in a tightly sealed container to prevent moisture, and it is best to keep it in a cool temperature between 1 and 25 degrees Celsius. Proper storage helps maintain the drug's effectiveness for a longer time.

Appearance

White or nearly white oval film-coated tablet

Package unit

80 tablets (10 tablets/PTP) x 8, 100 tablets (10 tablets/PTP) x 10