EGF Topical Solution 0.005% (Recombinant Human Epidermal Growth Factor)

Adult use

After mixing this drug with the accompanying solvent thoroughly, apply an appropriate amount to the affected area twice a day.

This drug should not be used in patients with hypersensitivity to the active ingredient. It is also advisable not to use this drug in patients with malignant tumors at the application site or a history of malignant tumors. Patients with systemic or localized infections should only use this drug after the infection has been adequately treated and improved. Patients with a history of malignant tumors should use this drug cautiously. The use of this drug may result in pain, redness, hyperplasia at the application site, elevated liver enzymes, as well as pain in the back or muscles, and neck area. In clinical trials, ulcers, pain and infection at the ulcer site, and elevated liver enzymes were reported as side effects in patients using this drug. After use, redness of the skin or excessive tissue growth may occur, requiring caution. Patients with diabetic foot ulcers and conditions such as sepsis, osteomyelitis, abscess, connective tissue diseases, a history of malignant tumors, or poor nutritional status have not had the safety and efficacy of this drug established, so caution is advised in these cases. It is important to confirm the presence of malignant tumors before using this drug. The safety of this drug has not been established in pregnant or breastfeeding women, so it is best to avoid use. This drug has not been studied for safety and efficacy in children, so its use is not recommended. This drug should be used on areas of the wound that have good blood circulation and are free of infection. The wound area should be cleaned with sterile saline before use. This drug has no antibacterial action, so infection treatment is necessary for infected wounds before its use. When used, it is important to mix the active ingredient with the accompanying solvent. Please verify that spraying works well when using for the first time. When spraying on the wound area, maintain a distance of about 5-10cm, and spray sufficiently to cover the entire wound. After application, dressing should be done only after waiting for it to completely dry. The mixed solution should be used within 6 months and must be stored refrigerated (2-8°C). It is safe to store it out of reach of children.

Serious side effects

• Swelling at the ulcer site
• elevated liver enzymes
• infection at the ulcer site
• edema.

Mild side effects

• Pain at the application site
• redness
• hyperplasia
• back pain
• muscle pain
• neck pain
• pain at the ulcer site
• fever at the ulcer site
• redness
• itching

This drug should be stored in a tightly sealed container to prevent exposure to air or moisture. Also, it is important to store it in the refrigerator at a temperature between 2 to 8 degrees Celsius to maintain freshness and effectiveness.

Appearance

A colorless, transparent liquid in a pump spray bottle divided into two compartments, which forms a colorless, transparent topical solution when mixed with the accompanying solvent.

Package unit

1 unit/box [10ml (spray bottle)]