Esride Tablet (Roxithromycin)

Adult dose

Adults: Administer 150㎎ (potency) of roxithromycin orally twice daily, in the morning and evening before meals. For pneumonia, administer 300mg (potency) once daily before breakfast. Adjust the dose as appropriate according to age and symptoms.

Child dose

Children: The average dose used in clinical trials was 6mg (potency)/kg of body weight daily. Administer 5～8mg (potency)/kg of body weight daily orally in 2 divided doses. The doses according to body weight are as follows: - Children usually weighing 6～11Kg: Take 25mg (potency) per dose twice daily before meals (pediatric tablets and granules only), or 2.5mL per dose twice daily before meals (suspension only). - Children weighing 12～23Kg: Take 50mg (potency) per dose twice daily before meals (pediatric tablets and granules only), or 5mL per dose twice daily before meals (suspension only). - Children weighing 24～40Kg: Take 100mg (potency) per dose twice daily before meals (pediatric tablets and granules only), or 10mL per dose twice daily before meals (suspension only).

This medication can rarely cause serious skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and acute generalized exanthematous pustulosis, therefore, if skin blistering or progressive skin rashes, such as mucosal damage, occurs, usage should be stopped immediately. This medication should not be used in individuals allergic to this drug or macrolide antibiotics, or for those taking certain heart-related medications or ergot alkaloids. Special caution is needed for patients with impaired liver function or the elderly. Coadministration with other antibiotics may lead to resistance issues or heart rhythm abnormalities. This medication can worsen myasthenia gravis, so caution is advised for patients with this history. There can be rare occurrences of severe allergic reactions like anaphylactic shock; if symptoms appear, treatment should be discontinued immediately and proper therapy should be sought. This medication may cause a variety of side effects such as fever, rash, reduction in blood cell counts, liver function impairment, gastrointestinal symptoms (nausea, vomiting, abdominal pain, diarrhea, etc.), respiratory distress, neurological symptoms (drowsiness, dizziness), changes in taste and smell, skin reactions, hearing impairment, or vision disturbances. If any symptoms occur, consult a healthcare professional. Long-term use may decrease the number of beneficial intestinal bacteria, leading to other infections; hence, monitoring the condition is essential. This medication can increase the blood levels of several drugs metabolized in the liver, raising the risk of cardiac arrhythmias, and thus should not be administered with specific drugs. It can also increase the bleeding risk of medications like warfarin, requiring caution. Pregnant women or those who may become pregnant should use this medication only when necessary, as it may affect the fetus, and nursing mothers should stop breastfeeding as this drug is transmitted in small amounts through breast milk. The elderly may experience an extended half-life of the drug in the body, but general dosage adjustments are not necessary. Symptoms like dizziness or blurred vision may arise, necessitating caution when operating machinery or driving. This medication should be stored out of the reach of children, and transferring it to another container may adversely affect its quality.

Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, shock, anaphylactic shock, fever, rash, allergic skin reactions, angioedema, eosinophilia, agranulocytosis, leukopenia, thrombocytopenia, cholestatic acute hepatitis, hepatocellular acute hepatitis, jaundice, elevated AST, elevated ALT, elevated ALP, increased serum bilirubin, anorexia, nausea, vomiting, upper abdominal discomfort, gastralgia, abdominal pain, abdominal distension, diarrhea, membranous colitis, loose stools, hemorrhagic colitis, bloody stools, pancreatitis, bronchospasm, cough, dyspnea, abnormal chest X-ray, interstitial pneumonia, drowsiness, headache, dizziness, tongue numbness, paralysis, dysgeusia, ageusia, olfactory disorders, loss of smell, erythema multiforme, purpura, superinfection due to overgrowth of non-susceptible pathogens, transient hearing loss, auditory impairment, visual disturbances, blurred vision, conjunctival injection, general malaise, weakness, palpitations, QT prolongation, ventricular tachycardia, arthralgia, epistaxis, menstrual irregularities, inflammation of oral and vaginal mucosa, hallucinations, confusion

This medication should be stored in a sealed container to prevent air or moisture ingress and should avoid direct sunlight, preferably stored at room temperature. Room temperature typically refers to a temperature between 15 to 25 degrees Celsius, and extremes in temperature should be avoided.

Appearance

Biconvex white round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle