Exen Tablet (Ofloxacin)

Adult dosage

○ Adults usually take 300～600 mg of ofloxacin in 2～3 divided doses daily. ○ For Hansen's disease, take 400～600 mg of this medicine in 2～3 divided doses daily. In principle, use in combination with other anti-Hansen's disease drugs. The dose may be adjusted appropriately according to age and symptoms.

This drug is a fluoroquinolone antibiotic and may cause serious side effects such as tendinitis, tendon rupture, peripheral neuropathy, central nervous system disorders, and exacerbation of myasthenia gravis. If these symptoms occur, the medication should be stopped immediately and it should not be used in patients with myasthenia gravis. This drug is recommended for use only when there are no other treatment options available for acute bacterial sinusitis, acute exacerbations of chronic bronchitis, and uncomplicated urinary tract infections. The risk of tendon rupture increases in the elderly or when used in combination with steroids, so treatment should be discontinued and rest taken if there are symptoms of pain or inflammation. Myasthenia gravis patients should be cautious as symptoms may worsen due to neuromuscular blocking effects. This drug may cause various side effects, including hypersensitivity reactions, renal and hepatic dysfunction, gastrointestinal issues, blood abnormalities, neurological disorders, skin diseases, musculoskeletal issues, respiratory and circulatory system problems. Particularly, serious cardiovascular abnormalities such as cardiac valve regurgitation or aneurysm may occur, so medical attention should be sought immediately if symptoms appear. While taking this drug, unnecessary sun exposure should be avoided, and if any phototoxicity symptoms occur, the medication should be discontinued. Moreover, patients at risk for neurological disorders should be cautious, as neurological symptoms may arise. Regular assessments of liver and kidney functions and blood tests are recommended during treatment, and adequate hydration should be maintained to reduce renal burden. Neurological abnormalities such as dizziness may occur, requiring caution when driving or operating machinery. This drug may interact with certain foods or other medications, so consultation with a doctor or pharmacist is necessary if any co-administered medications are present. It should not be used in pregnant or breastfeeding women, growing children and adolescents, or patients with specific genetic disorders, and dose adjustments are needed for the elderly due to decreased renal function. In case of overdose, immediate medical attention should be sought, and intravenous injections should be administered slowly to prevent side effects such as hypotension. This drug should be stored out of reach of children and not transferred to other containers.

Tendinitis, tendon rupture, peripheral neuropathy, central nervous system effects, exacerbation of myasthenia gravis, anaphylactic shock, anaphylactic reactions, rash, itching, erythema, edema, fever, warmth, vesicles, erythema, photosensitivity reactions, hematuria, acute renal failure, kidney stones, interstitial nephritis, elevated BUN, elevated serum creatinine, jaundice, liver failure, elevated AST/ALT, elevated ALP, elevated γ-GTP, elevated total bilirubin, cholestatic jaundice, fulminant hepatitis, pseudomembranous colitis, abdominal pain, frequent diarrhea, nausea, vomiting, stomach and abdominal discomfort, diarrhea, cirrhosis, loss of appetite, stomach pain, dyspepsia, chest pain, thirst, taste disturbance, stomatitis, glossitis, abdominal bloating, constipation, dysphagia, gastrointestinal bleeding, oral mucosal pain, intestinal perforation, anemia, leukopenia, decreased hemoglobin, decreased hematocrit, thrombocytopenia, eosinophilia, agranulocytosis, thrombotic thrombocytopenic purpura, petechiae and ecchymosis, prolonged prothrombin time, reversible bone marrow suppression, lymphocytopenia, neutropenia, elevated ESR, insomnia, dizziness, headache, seizures, tremors, numbness, peripheral neuropathy, visual disturbances, auditory disturbances, hallucinations, drowsiness, neuroexcitability, sleep disorders, confusional state, anxiety, depression, restlessness, dysphoria, confusion, seizures, nightmares, delirium, perceptual disturbances, reversible olfactory and vestibular sensory disturbances, ataxia, aphasia, heaviness in the head, mucocutaneous syndrome, toxic epidermal necrolysis, arthralgia, myalgia, muscle weakness, myositis, rhabdomyolysis, pharyngitis, dyspnea, bronchospasm, allergic pneumonia, epistaxis, stridor, fever, cough, abnormal chest X-ray, eosinophilia, interstitial lung disease, cerebral thrombosis, pulmonary edema, tachycardia, hypertension, hypotension, palpitations, vasodilation, circulatory collapse, QT prolongation, ventricular tachycardia, dysuria, polyuria, urinary retention, anuria, polyuria, hematuria, storage urine, pyuria, diabetes, proteinuria, alkaluria, vaginitis, vaginal candidiasis, increased vaginal discharge, vulvar itching in women, irregular menstruation, uterine cramps, female genital rash, pain, irritation, burning sensation, symptoms of hypoglycemia, limb pain, malaise, fever, drowsiness, nausea, dizziness, facial flushing, facial edema, numbness, inaccurate speech, loss of directional sense

This drug should be stored in a tightly sealed container to prevent air from entering, ideally at a temperature between 1 and 30 degrees Celsius. Proper storage conditions help maintain the effectiveness of the medication for a longer time.

Appearance

White round film-coated tablet (For export: white round film-coated tablet)

Package unit

30 tablets/bottle, 500 tablets/bottle