Sinil Monodoxim Capsule (Doxycycline Hydrate)

Adult dose

Adults: The initial dose is 100 mg (potency) of doxycycline orally every 12 hours. The maintenance dose is 100 mg (potency) per day, divided into 1 ∼ 2 doses. For severe infections, administer the initial dose every 12 hours. This medicine should be continued for an additional 24 ～ 48 hours after symptoms have subsided and the fever has resolved. For streptococcal infections, continue treatment for at least 10 days to prevent the development of rheumatic fever or glomerulonephritis. Adjust the dose as appropriate according to age and symptoms.

Child dose

Adolescents 12 years and older: For those weighing 45 kg or less, the initial dose is 4 mg (potency)/kg of body weight per day, administered orally in 2 divided doses. The maintenance dose is 2 mg (potency)/kg of body weight per day, administered in 1 ∼ 2 divided doses. Adolescents 12 years and older: For those weighing more than 45 kg, administer the dose corresponding to the adult dose.

This medication can cause diarrhea due to Clostridium difficile infection, which may lead to colitis ranging from mild to life-threatening. If diarrhea symptoms occur after antibiotic use, it is essential to get tested and receive appropriate treatment at a medical facility. Serious skin adverse effects such as severe allergic reactions, dermatitis, or mucosal damage may occur during the intake of this medication. If these symptoms appear, discontinue use immediately and consult with a healthcare professional. Individuals with allergies to this medication, its components, or similar classes of antibiotics should not use it. Pregnant or breastfeeding women, as well as children under 12 years, should avoid using this medication for safety reasons. Particularly in children, caution is advised due to potential tooth discoloration or impact on bone growth. Patients with severely impaired kidney or liver function and specific muscle disorders should also avoid its use. Patients with impaired kidney function need to adjust the dosage of this medication and check drug levels in the blood during prolonged use. This medication can cause severe skin reactions from sunlight exposure, so while taking it, avoid direct sunlight or UV exposure, and stop use immediately if a rash develops on the skin. Caution is required if taken alongside drugs that may cause liver toxicity or if there are existing liver conditions. This medication can cause esophagitis or esophageal ulcers; hence, it should be taken with a sufficient amount of water while standing and should not be taken just before bedtime. When experiencing gastrointestinal discomfort during usage, it is advisable to take it with food. This medication may interact with other drugs; thus, especially when taking oral contraceptives, antacids, iron supplements, anticoagulants, or immunosuppressants, consult with a physician or pharmacist. Women who are pregnant or may become pregnant should not use this medication, and those who are breastfeeding should either stop breastfeeding or avoid its use while taking it. Children, especially those under 12 years, should ideally avoid using this medication, and older adults may require dose adjustments and monitoring of their condition. In case of overdosing, symptoms such as vomiting, liver and kidney damage, and esophagitis may occur, so seek appropriate treatment at a medical institution immediately. This medication should be stored out of the reach of children and kept in its original container for safety.

Diarrhea, colitis, exfoliative dermatitis, erythema multiforme, mucosal blistering syndrome, toxic epidermal necrolysis, drug reaction accompanied by eosinophilia and systemic symptoms, hemolytic anemia, neutropenia, thrombocytopenia, hypersensitivity, anaphylactic shock, angioedema, exacerbation of systemic lupus erythematosus, pericarditis, serum sickness, hypotension, dyspnea, tachycardia, peripheral edema, urticaria, thyroid microscopic brown discoloration, decreased appetite, headache, benign intracranial hypertension, retching, tinnitus, flushing, nausea, vomiting, dyspepsia, pancreatitis, membranous enterocolitis, esophageal ulcer, esophagitis, enterocolitis, perianal genitourinary inflammatory lesions, dysphagia, abdominal pain, glossitis, tooth discoloration, hepatotoxicity, hepatitis, abnormal liver function, photosensitivity reactions, rash, photokeratolysis, exfoliative dermatitis, arthralgia, myalgia, increased BUN, anemia, granulocytopenia, atypical lymphocytes, lymphocytopenia, lymphadenopathy, blood coagulation disorder, fever, dysesthesia, anxiety, restlessness, severe colitis accompanied by bloody stools, loose stools, stomatitis, sore throat, black hairy tongue, hoarseness, jaundice, onycholysis, nail color change, fixed drug eruption, arthritis, renal damage, interstitial nephritis, acute kidney failure, oliguria, hematuria, visual disturbances, optic disc edema, decreased and loss of olfactory and gustatory function, vitamin K deficiency, symptoms of vitamin B complex deficiency, facial, tongue, and laryngeal edema, yellow urine, reduced urine glucose, liver and kidney parenchymal damage, anaphylactic reaction

This medication is sensitive to air and light, so it should be stored in a tightly sealed container. Additionally, it must be kept in a cool and dark place at room temperature between 1°C and 30°C to maintain its effectiveness.

Appearance

A green capsule filled with a light yellow powder.

Package unit

90 capsules (6 capsules/blister*15), 100 capsules/bottle, 500 capsules/bottle, 90 capsules (10 capsules/PTP*9)