Iyeon Cefazodone Injection 1G (For Injection) (Cefazodone Sodium)

Adult administration

For infections caused by gram-positive bacteria, 1–2g (potency) should be administered by intravenous injection divided into 2–3 doses daily. For infections caused by gram-negative bacteria, administer 3–4g (potency) divided into 2–3 doses daily. For life-threatening infections and infections caused by moderately susceptible bacteria, the dose may be increased up to 6g (potency) daily. For patients with renal impairment, dosing and intervals should be adjusted according to the degree of renal damage.

This medication should not be administered to certain patients as it is a cephalosporin antibiotic. Patients who have had allergic reactions to cephalosporin antibiotics, premature infants, or newborns should not use this medication. Pregnant women within the first three months of pregnancy or patients with kidney and liver function issues should use this medication with caution. Patients with hemophilia or thrombocytopenia, as well as those with gastrointestinal ulcers, require attention. Additionally, patients who have difficulty with oral intake, those receiving parenteral nutrition, elderly patients, and those in poor overall condition may exhibit symptoms of vitamin K deficiency, hence careful monitoring is necessary. Various adverse reactions can manifest, ranging from mild hypersensitivity symptoms such as headache, dizziness, nausea to severe allergic reactions like skin rashes, fever. Caution is warranted. Liver function test values may temporarily rise, and transient leukopenia may occur. In the gastrointestinal tract, severe colitis, abdominal pain, diarrhea, nausea, vomiting, and anorexia may occur; these symptoms should prompt immediate notification to medical personnel. Rare respiratory symptoms include interstitial pneumonia or dyspnea; thus, respiratory symptoms should be monitored carefully. Dysbiosis such as stomatitis or candidiasis may occur, and symptoms of vitamin K and B complex deficiency may also rarely present. To prevent the occurrence of resistant bacteria, this medication should be used only for the necessary minimum duration based on susceptibility test results. Before administration, thorough questioning and skin tests are recommended to minimize the risk of allergic reactions or shock; even after administration, the patient should be observed in a stable condition. When used in conjunction with other antibiotics or diuretics that may affect kidney function, caution is required as renal impairment may worsen. When used with high doses of oral anticoagulants that may affect blood coagulation, monitoring for the risk of bleeding is necessary. Women who are breastfeeding should be cautious as this medication may be secreted in small amounts in breast milk. Finally, this medication should not be mixed with other antibiotics when placed in an injection syringe and should be administered alone.

Serious side effects

Anaphylaxis (severe allergic reactions such as hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor), severe colitis (possibly with high fever, severe rash, blisters, skin peeling, mucosal pain in mouth/eyes), dyspnea, asthma attacks, respiratory abnormalities accompanied by cough and fever, interstitial pneumonia, PIE syndrome, jaundice (yellowing of the skin or eyes), extreme lethargy throughout the body

Mild side effects

Transient mild headache, dizziness, nausea, skin rash, fever, increased liver enzymes (AL-P, GOT, GPT), transient leukopenia, abdominal pain, frequent diarrhea, vomiting, anorexia, stomatitis, candidiasis, vitamin K deficiency symptoms (hypoprothrombinemia, tendency to bleed), vitamin B complex deficiency symptoms (glossitis, stomatitis, anorexia, neuritis)

This medication should be stored in a sealed container to prevent contact with air and should ideally be kept at room temperature between 1 degree and 30 degrees Celsius. This storage method helps to maintain the medication's efficacy for a longer period.

Appearance

A colorless transparent vial filled with a white to pale yellow powder

Package unit

1g/vial × 10