Clavulin Tablets (Amoxicillin · Clavulanate Potassium)

Adult dose

Adults and children aged 12 years or older, or weighing 40 kg or more, should take Amoxicillin/Clavulanate potassium at a dose of 250 mg/125 mg orally three times a day every 8 hours. In case of severe and respiratory infections, the dose may be increased to 500 mg/125 mg. In patients with renal impairment, dosing must be adjusted according to creatinine clearance. - Creatinine clearance of 10 to 30 mL/min: administer 250 to 500 mg every 12 hours.

Child dose

Children under 12 years or weighing less than 40 kg should be administered the adult dosage adjusted accordingly.

This medication is a beta-lactam antibiotic and should not be used in patients who have had hypersensitivity reactions to penicillins or cephalosporins. Special caution is needed for patients with infectious mononucleosis or lymphocytic leukemia due to a higher risk of rash. Patients with liver function impairment should be cautious as this medication may exacerbate liver dysfunction. Those with liver impairment or severe renal failure may experience increased drug concentrations necessitating dosage and interval adjustments. Patients with allergies, the elderly, or those in poor health should use it carefully due to a higher risk of side effects. Gastrointestinal symptoms such as abdominal pain, diarrhea, and vomiting may occur; taking it with food may reduce gastrointestinal adverse effects. Liver enzyme levels may rise, and rarely hepatitis or jaundice may occur, hence liver function tests are needed during prolonged use. If there is skin rash, itching, or severe skin reactions, immediate discontinuation and medical attention are required. Rarely, blood abnormalities may be reported; caution is necessary if signs of bleeding tendencies or anemia are observed. Central nervous system anomalies may present as anxiety, confusion, or seizures; immediate notification is necessary if such symptoms arise. Patients with decreased kidney function risk kidney damage, hence regular monitoring is warranted. Antibiotic use may disrupt the intestinal bacterial balance, leading to fungal infections or stomatitis, requiring treatment if symptoms arise. There is a bleeding risk due to vitamin K deficiency; those on long-term therapy or the elderly should be particularly cautious. This medication may interact with other drugs, so it is essential to inform the healthcare provider of any other medications being taken. Women who are pregnant or nursing should consult a doctor before use; especially in early pregnancy, it is advisable to avoid administration. Use in children under 12 years is not recommended, and dosage adjustments and monitoring are needed in the elderly due to a higher likelihood of side effects.

Serious side effects

Urticaria, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, high fever with severe rash, blisters, skin peeling, oral/eye mucosal pain, severe cutaneous adverse reactions, asthma attack, respiratory distress accompanied by cough and fever, breathing problems, jaundice (yellowing of skin or eyes), severe and sudden headache, thunderclap headache, seizures

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• black hairy tongue
• nausea
• vomiting
• anorexia

This medication should be stored in a tightly sealed container to prevent moisture, in a dry place below 25 degrees Celsius. Proper storage will maintain the drug's efficacy and prevent degradation.

Appearance

White to almost white oval film-coated tablet

Package unit

(10 tablets/PTP) × 10