Genosef Injection 500 mg (Cefazolin Sodium)

Adult administration

For infections caused by gram-positive bacteria, administer 1–2 g (potency) of Cefazolin Sodium divided into 2–3 intravenous doses daily. For infections caused by gram-negative bacteria, administer 3–4 g (potency) divided into 2–3 doses daily. In cases of life-threatening infections and moderate susceptibility bacteria infections, the dosage may be increased up to 6 g (potency) daily. For intravenous injection, dissolve 1 g (potency) of this drug in 5 mL of sterile water and infuse over 2–3 minutes.

This drug should not be used in patients with hypersensitivity to cephalosporin antibiotics. It is also advisable not to administer this drug to premature infants and newborns. Pregnant women in the first trimester should use this drug with caution, and patients with poor kidney or liver function need to be careful as well. Patients with hemophilia or thrombocytopenia and those with gastrointestinal ulcers should use this medication cautiously. Patients who have difficulty with oral intake, who rely on parenteral nutrition, the elderly, and patients in poor overall condition should be closely monitored for signs of vitamin K deficiency. Mild adverse reactions such as transient headaches, dizziness, and nausea may occur when using this drug, and rarely, skin rashes, fever, or severe allergic reactions can occur, in which case the drug should be discontinued immediately and medical consultation should be sought. Liver function test values may temporarily increase, and a decrease in white blood cell count may also occur rarely. Inflammation in the gastrointestinal tract may lead to severe abdominal pain or diarrhea, requiring immediate discontinuation of the medication if such symptoms occur. Respiratory symptoms such as fever, cough, and difficulty breathing may also appear, so patients should notify medical staff immediately if these symptoms arise. Rarely, dysbiosis, such as stomatitis or candidiasis, can occur. Symptoms of vitamin K and vitamin B complex deficiencies may appear, necessitating appropriate action if needed. To prevent the emergence of resistant bacteria, it is important to administer this drug only for the minimum duration required as determined by susceptibility testing. Before use, thorough medical history inquiries and skin testing should be conducted to prevent allergic reactions. Emergency measures should be prepared for acute allergic reactions, and patients should be closely observed in a stable state after administration. This drug should be used with reference to susceptibility testing results due to increasing resistance to first-generation cephalosporin antibiotics. Caution is required when used concurrently with aminoglycoside antibiotics as they may affect kidney function. The risk of renal impairment increases when used in conjunction with Polymyxin B, colistin, or high-dose diuretics, so it should be administered with caution. When used with high-dose oral anticoagulants, it may affect blood coagulation; therefore, blood conditions should be carefully monitored. Breastfeeding women should use this medication cautiously as it may be transmitted in small amounts through breast milk. Lastly, this medication should not be mixed with injections of aminoglycoside antibiotics in the same syringe.

Serious side effects

Anaphylaxis (severe allergic reaction), dyspnea, interstitial pneumonia, PIE syndrome, symptoms of vitamin K deficiency (bleeding tendency), shock

Mild side effects

• Transient mild headache
• dizziness
• nausea
• skin rash
• fever
• vomiting
• loss of appetite
• glossitis
• stomatitis
• neuritis

This medication should be stored in a tightly closed container that protects it from light, ideally at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the drug's effectiveness for a longer period.

Appearance

A white to yellowish powder in a brown vial injection

Package unit

1 vial X 1