Genosef Injection 2 grams (Cefepime Sodium)

Adult administration

For infections caused by gram-positive bacteria, 1 to 2g (potency) should be administered as a divided intravenous injection 2 to 3 times a day. For infections caused by gram-negative bacteria, 3 to 4g (potency) should be administered as a divided dose 2 to 3 times a day. For life-threatening infections and infections caused by moderately susceptible bacteria, the dose may be increased up to 6g (potency) per day. For patients with impaired kidney function, the dose and administration interval should be determined according to the degree of kidney impairment.

This drug should not be used in patients allergic to cephalosporin antibiotics. It is particularly unsafe to administer to premature and newborn infants. It should be used with caution in pregnant women during the first three months of pregnancy, patients with kidney or liver problems, patients with blood coagulation disorders, and patients with ulcers in the gastrointestinal tract. Moreover, patients who do not eat well or receive parenteral nutrition, elderly patients, and patients in poor general condition should be monitored closely for signs of vitamin K deficiency. Mild hypersensitivity reactions such as headache, dizziness, and nausea may occur with this medication, and rarely, skin rashes, fever, or severe allergic reactions may develop; if these symptoms appear, administration should be stopped immediately, and treatment should be sought. Liver function tests may show temporary increases, and white blood cell counts may temporarily decrease. If gastrointestinal issues arise that cause severe abdominal pain or diarrhea, administration should be stopped. If respiratory symptoms such as fever, cough, or difficulty breathing occur, medication should be stopped, and appropriate treatment should be provided. Disruption of flora such as stomatitis or candidiasis may occur rarely. Signs of vitamin K and vitamin B complex deficiency may appear, and caution is needed for these symptoms. To prevent the development of resistant bacteria, it is important to conduct sensitivity testing and administer for only the minimum necessary duration. To prepare for possible allergic reactions or shock, the patient's condition should be thoroughly assessed, and the patient should be monitored consistently after administration. When used with other antibiotics, caution should be exercised as renal function may be affected. If breastfeeding, caution should be exercised as some drugs may be passed into breast milk. Lastly, this drug should not be mixed and injected with other specific antibiotics.

Serious side effects

Severe colitis (with blood in stools), anaphylaxis, interstitial pneumonia, PIE syndrome, difficulty breathing, abnormal chest X-ray findings, respiratory distress accompanied by fever and cough

Mild side effects

Mild headache, dizziness, nausea, skin rash, fever, transient leukopenia, abdominal pain, frequent diarrhea, vomiting, loss of appetite, stomatitis, candidiasis, signs of vitamin K deficiency (hypoprothrombinemia, tendency to bleed), signs of vitamin B complex deficiency (stomatitis, stomatitis, loss of appetite, neuropathy)

This medication is sensitive to light and should be stored in a container that does not allow light in. It is best stored at room temperature, avoiding excessively hot or cold conditions.

Appearance

A white to yellowish powder in a brown vial for injection

Package unit

1 vial x 10