Gurumeformin Tablets 500 mg (Metformin Hydrochloride)

Adult dose

The dosage should be determined based on individual drug effects and tolerance, and should not exceed the recommended maximum daily dose. This drug should start at a low dose to reduce gastrointestinal side effects and to confirm the minimum effective dose required for adequate blood glucose control, and should be taken 500mg two to three times a day with meals. Dosage increases should be gradual, at 500mg per week, until reaching 20...

Child dose

For children over 10 years or adolescents in growth, the usual starting dose is 500mg once a day taken during or after a meal. After one week, blood glucose levels should be measured to adjust the dosage.

This drug can cause severe lactic acidosis or hypoglycemia, so it should be used with extreme caution. It should not be administered to patients with moderate to severe renal impairment, dehydration, severe infections, or cardiovascular problems. Furthermore, its administration must be stopped before and after certain radiologic examinations using contrast agents, and can only be resumed after renal function has returned to normal. It should also not be used in patients with hypersensitivity to this drug, type 1 diabetes, or metabolic acidosis. In cases of severe infections, serious trauma, or during surgery, the drug should be temporarily discontinued and can be resumed only after the patient's condition stabilizes and renal function has been confirmed to be normal. Careful attention should also be paid to malnutrition, liver dysfunction, lung function decline, and excessive alcohol consumption. Patients with irregular meals or engaging in vigorous exercise, as well as those taking interacting medications, should be administered with caution due to the risk of lactic acidosis and hypoglycemia. Lactic acidosis is very rare but can be fatal, with initial symptoms including fatigue, muscle pain, breathlessness, and abdominal pain, which should prompt immediate notification to healthcare professionals. Gastrointestinal side effects may include diarrhea, nausea, vomiting, and abdominal pain, which usually occur initially but subside gradually. As this drug is excreted through the kidneys, regular renal function tests should be conducted, and administration should be immediately stopped if renal function declines. Alcohol can worsen the side effects of this drug, so excessive drinking should be avoided during treatment. Monitoring for vitamin B12 deficiency through regular blood tests is recommended. During pregnancy, it may affect the fetus, so consultation with a physician is necessary if pregnancy is planned or confirmed, and treatment should be ceased if fetal growth abnormalities are detected. If breastfeeding, careful consideration should be given to whether to continue breastfeeding or discontinue the drug, as this drug is secreted in breast milk. Elderly patients may have reduced renal function, so treatment should start at lower doses with frequent monitoring of renal function. This drug may interact with other hypoglycemic agents or multiple medications, so patients should inform healthcare providers of all medications they are taking, and blood glucose levels should be frequently monitored. In the event of an overdose, blood dialysis may be required, and immediate contact with a medical facility is necessary. This drug does not cause weight gain, making it favorable for weight management and can be used in children or adolescents, but should be used cautiously in children under 10 years. Lastly, this drug should be kept out of reach of children and not transferred to other containers for safety.

Serious side effects

Lactic acidosis, severe edema accompanied by increased blood pressure, acute renal failure, liver abnormalities (jaundice), severe allergic reactions (including rash), serious neurological symptoms, respiratory problems (difficulty breathing), severe skin reactions

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain), metallic taste discomfort, rashes, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver dysfunction, severe delayed hypoglycemia, hypoglycemic symptoms, failure in blood sugar control, megaloblastic anemia

This drug should be stored in a sealed container to protect it from air and moisture. It is also important to keep the drug at room temperature, not too hot or too cold.

Appearance

It is a white, round film-coated tablet.

Package unit

30 tablets/bottle, 100 tablets/bottle, 500 tablets/bottle, 1000 tablets/bottle