Plasma Solution A Injection

Adult administration

Generally, for adult patients, 500 to 1,000 mL is administered via dripping intravenous infusion. The infusion rate should be at 200 mL per hour. The dosage and rate of administration should be adjusted appropriately based on age, weight, and symptoms.

This medication can cause serious allergic reactions, such as anaphylaxis, during use; if such symptoms occur, administration should be stopped immediately and appropriate treatment sought. This medication contains potassium, and in patients with poor kidney function, dehydration, or heart disease, serum potassium levels may become dangerously high, necessitating caution. Additionally, this medication contains sodium and chloride ions, which may cause electrolyte imbalances such as hypernatremia, fluid overload, edema, and metabolic acidosis; therefore, it should be used with caution in patients with hypertension, liver disease, and heart failure. It may cause hyponatremia, particularly in children, the elderly, postoperative patients, and those with mental health disorders, so sodium levels should be frequently monitored in these groups; severe hyponatremia may present with headaches, vomiting, seizures, and other symptoms. Intravenous administration of this medication may worsen conditions such as pulmonary edema or congestive heart failure due to excessive fluid supply; therefore, fluid status and electrolyte levels should be monitored regularly. This medication should not be administered in cases of fluid overload, hypernatremia, or in patients who have had hypersensitivity reactions to it. Patients with congestive heart failure, renal failure, hyperkalemia, metabolic alkalosis, liver dysfunction, and severe renal impairment should use this medication with extra caution. There may be a feeling of warmth, infections, thrombosis, phlebitis, exudate, hypervolemia, generalized papules and erythema, rashes, vomiting, hypertension, tachycardia, hyperkalemia, hyponatremia, hypernatremia, hyperchloremic acidosis, fluid overload, and hyponatremic encephalopathy at the injection site, and rapid administration may lead to side effects such as cerebral edema, pulmonary edema, and metabolic alkalosis. Due to its high sodium content, care should be taken when administering this medication to patients undergoing corticosteroid therapy, and it is important to regularly check blood glucose, electrolytes, and fluid balance. Concomitant use with medications that cause hyperkalemia poses a risk of severe hyperkalemia; therefore, patients taking such medications should avoid this medication or closely monitor serum potassium levels. When used in conjunction with drugs that increase the risk of hyponatremia, caution is required as the risk of developing hyponatremia increases. The administration of this medication in pregnant women or those who may become pregnant should be made with careful consideration, and children and the elderly should be administered with close observation of electrolyte imbalances and fluid status. This medication's container is made of PVC material containing DEHP; however, the risk associated with this is very low, and the risk of not using this medication is greater, so there is no need to worry.

Serious side effects

Severe allergic reactions (including anaphylaxis) presenting as hives, severe swelling (edema), chest tightness, difficulty breathing, paleness, cardiac arrest, cerebral edema, pulmonary edema, peripheral edema, significantly reduced urine output, edema associated with elevated blood pressure, headache, seizures, confusion, visual disturbances due to hyponatremia, risk of severe brain injury, severe neurological symptoms, severe allergic reactions, liver-related symptoms (jaundice) are included.

Mild side effects

• Warmth at the injection site
• infection
• venous thrombosis
• phlebitis
• exudate
• hypervolemia
• generalized papules and erythema
• rashes
• vomiting
• hypertension

This medication should be stored in a tightly sealed container to prevent air or moisture from entering, away from direct sunlight, and at room temperature. Proper storage helps maintain the medication's efficacy and prevent degradation.

Appearance

A colorless and transparent injection prepared in a plastic container filled with colorless and transparent solution, packaged in a high-density polyethylene that is translucent on the outside.

Package unit

500, 1000 milliliters