Cefepime Sodium Injection 1 Gram

Adult administration

For cefepime sodium, in the case of infections caused by Gram-positive bacteria, 1-2g (potency) is administered as an intravenous injection divided into 2-3 doses per day. For infections caused by Gram-negative bacteria, 3-4g (potency) is administered as an intravenous injection divided into 2-3 doses per day. For life-threatening infections and infections by moderately susceptible bacteria, the dosage may be increased up to 6g (potency) per day. The injection solution is prepared by dissolving 1g (potency) of this medication in 5mL of injection water for intravenous injection over 2~

This medication is a cephalosporin antibiotic and should not be administered to certain patients. Patients with allergies to cephalosporin antibiotics, premature infants, and newborns should not use this medication. It should be used carefully in pregnant women within the first three months, patients with kidney or liver function issues, patients with blood coagulation disorders, and those with gastrointestinal ulcers. Additionally, patients who have difficulty swallowing, elderly patients, and those in poor overall condition should be carefully monitored for symptoms of vitamin K deficiency. Mild hypersensitivity reactions such as headache, dizziness, and nausea may occur with this medication, while severe allergic reactions such as skin rashes or anaphylaxis may occur rarely, and treatment should be sought immediately if symptoms appear. Liver function test values may rise temporarily, and there may be a transient decrease in white blood cell count. If severe inflammation occurs in the gastrointestinal tract resulting in abdominal pain or diarrhea, the medication should be stopped immediately, and nausea, vomiting, loss of appetite may occur rarely. Respiratory-related side effects such as interstitial pneumonia or PIE syndrome have been reported rarely, and discontinuation of the medication and appropriate treatment should ensue if such symptoms are present. Gut dysbiosis such as stomatitis or candidiasis may also occur rarely. Symptoms of vitamin K and vitamin B deficiency may arise, so bleeding tendencies and neurological symptoms should be carefully monitored. It is important to administer this medication for the minimum necessary duration based on susceptibility test results to prevent the emergence of resistant bacteria. Adequate inquiry and skin reaction tests before administration are recommended to prevent allergic reactions or shock, and the patient should be well monitored in a stable condition afterward. In particular, resistance to first-generation cephalosporin antibiotics is increasing; therefore, susceptibility test results must be confirmed. This medication may affect kidney function when used with aminoglycoside antibiotics or certain diuretics and should be administered with caution. Additionally, co-administration with high-dose oral anticoagulants may affect blood coagulation; therefore, careful monitoring is advised. Lactating mothers should use this medication cautiously as it may transfer in small amounts to breast milk. Finally, this medication should not be mixed with aminoglycoside antibiotics in a syringe for injection.

Serious side effects

Anaphylaxis, severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweats, pallor), respiratory problems such as interstitial pneumonia, PIE syndrome, severe colitis, vitamin K deficiency symptoms (including tendency to bleed), fever, cough, difficulty breathing, abnormal chest X-ray findings, severe allergic reactions such as anaphylaxis

Mild side effects

Transient mild headache, dizziness, nausea, skin rash, fever, increased AL-P, GOT, GPT, transient leukopenia, stomatitis, candidiasis, nausea, vomiting, loss of appetite, stomatitis, neuritis, gastrointestinal reactions associated with vitamin B deficiency, severe colitis with bloody stools, abdominal pain, frequent diarrhea

This medication should be stored in a sealed container to prevent exposure to air or moisture. It is advisable to maintain storage temperatures between 1 and 30 degrees Celsius. Proper storage ensures the effectiveness and safety of the medication is preserved for an extended period.

Appearance

A colorless, transparent vial filled with white to yellowish powder.

Package unit

10 vials