Aynaminju

Adult administration

Generally, total amino acids are administered by intravenous infusion at a maximum dose of 1.5 g per kg of body weight per day (for a weight of 70 kg, this corresponds to 1300 mL per day). The administration rate is up to 1.25 mL per kg of body weight over 60 minutes.

This medication must be used strictly under the guidance of a physician. It should not be used in patients with poor kidney function or high nitrogen levels in the blood, those with liver dysfunction or issues with amino acid metabolism. It is also important not to administer to patients with weakened heart function or pulmonary issues, those not producing much urine, or those in metabolic acidosis. Patients with low sodium or in shock, and those with hypoxia should not use this medication. Patients with edema, diabetes, kidney disease, pulmonary disease, or a history of severe heart disease should use it cautiously. While using, allergic reactions like skin rashes may rarely occur, and gastrointestinal symptoms such as nausea or vomiting can also happen. Circulatory symptoms like heart discomfort, rapid heartbeat, or increased blood pressure may also appear, so caution is advised. Administering this medication too quickly or in excessive amounts can lead to metabolic acidosis from increased acidity in the body. Severe symptoms like chills, fever, headache, difficulty breathing, and shock may occasionally occur, so if unusual symptoms appear, immediate consultation with medical personnel is needed. This medication can cause various metabolic complications like metabolic acidosis, hypophosphatemia, alkalosis, and hyperglycemia. Patients with poor kidney function may experience increased blood urea nitrogen levels, so regular monitoring is necessary. Changes in blood ammonia levels should be carefully observed during treatment. Care must be taken regarding electrolyte balance in cases of large doses, and even more caution is required when used alongside other electrolyte solutions. Using too much of this medication can cause the blood to become alkaline, so caution is needed. Patients with kidney, lung, or heart disease should be administered carefully while avoiding excessive fluid supply. Diabetes patients should frequently check their blood sugar levels while using this medication. Regular blood tests for electrolytes, fluid balance, acid-base balance, blood sugar, proteins, and liver function are necessary. It is advisable to frequently monitor the injection site to prevent thrombosis. Using this medication alongside specific antibiotics may reduce its effectiveness, so caution is needed when using it in combination. This medication has a risk of microbial contamination, so it should not be mixed with other treatments and only with verified nutritional products. Pregnant or breastfeeding women should use this medication only when absolutely necessary and under the physician's judgment, as its safety has not been established. In children, liver function may be immature, so lower concentrations should be used, and blood ammonia levels should be frequently checked. Elderly patients may have reduced bodily functions, so the administration speed should be slower, and dosage should be adjusted accordingly. Because this medication contains electrolytes, care should be especially taken regarding electrolyte balance during large doses, and the infusion rate should also be slow. Rapid infusion can cause chills or vomiting, and there may be an increase in amino acid loss in the kidneys, so caution is needed. The solution should be warmed to body temperature before use, and preparation and handling must be done in asterile condition. Do not use if the solution is cloudy or discolored, and after preparation, it should be used quickly, limited to within 24 hours if refrigerated. If crystals form in the solution, warm them to dissolve, then cool to body temperature before use. When storing, do not open the package, and do not use if the solution leaks or is discolored. Make sure to accurately check the measuring scale on the container for use, and handle it safely.

Serious side effects

• Difficulty breathing
• respiratory arrest
• shock

Mild side effects

• Rash
• nausea
• vomiting
• chest discomfort
• palpitations
• increased heart rate (tachycardia)
• elevated blood pressure
• metabolic acidosis
• chills
• fever

This medication should be stored in a sealed container to prevent exposure to air, preferably at room temperature between 1°C to 30°C. Storing it this way helps maintain the medication's efficacy and prevents degradation.

Appearance

A colorless to pale yellow liquid filled in a colorless transparent glass bottle with a rubber stopper for injection.

Package unit

250 mL / bottle, 500 mL / bottle