Cefaxone Injection 1 gram (Ceftriaxone Sodium Hydrate)

Adult administration

Adults and children over 12 years: Administer 1-2 g (potency) of Ceftriaxone via intravenous or intramuscular injection once daily. In cases of severe illness or infections caused by moderately susceptible pathogens, the dose may be increased to 4 g (potency) once daily. For the treatment of gonorrhea when caused by penicillin-susceptible or resistant strains, a single intramuscular injection of 250 mg (potency) is recommended. For the prevention of infections before and after surgery, 1-2 g (potency) is recommended.

Child administration

Newborns (within 14 days of birth): Administer 20-50 mg/kg (potency) once daily, not exceeding 50 mg (potency). Administer to both preterm and term infants without distinction.

This medication should never be mixed or administered simultaneously with calcium-containing solutions or other medications due to the risk of dangerous precipitates. Especially in newborns under 28 days of age, administering this medication with calcium-containing solutions can cause life-threatening side effects, so it should not be administered. Individuals allergic to this medication or with hypersensitivity to cephalosporins or penicillins should not use it. This medication should not be given to premature infants or newborns at risk of bilirubin conjugation disorders, as it could risk causing bilirubin encephalopathy. Patients with severe renal impairment or a history of drug allergies should use this medication cautiously, and dosage or interval adjustments may be necessary. During treatment, regular monitoring of liver and kidney function, as well as blood tests, should be conducted, and if any abnormal signs appear, healthcare professionals should be consulted immediately. Rarely, side effects such as hives, rashes, diarrhea, and increased liver enzymes may occur, so report any symptoms immediately. In case of overdose, as there is no specific antidote, treatment should be symptomatic, and caution should be exercised regarding dizziness when driving or operating machinery. Pregnant or breastfeeding women should consult a doctor before using this medication, as it may affect the fetus or baby. Children and the elderly should be closely monitored and dosage adjusted as necessary, especially in neonates or premature infants where safety is a concern. This medication may interact with other drugs, so it is crucial to inform the healthcare provider of any current medications, especially when using calcium agents, diuretics, or aminoglycoside antibiotics. Injection sites may require observation for pain or inflammation; if an adverse reaction is suspected, administration should cease immediately, and treatment should be sought. This medication should be used as soon as possible after compounding, and if the compounded solution is not used within a certain timeframe, its efficacy may diminish.

Serious side effects

Hives, severe swelling (edema), severe allergic reactions, fever accompanied by severe rash, blisters, skin peeling, pain in oral/eye mucosa, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory distress accompanied by cough and fever, jaundice, profound lethargy, liver abnormalities (jaundice), sudden and very severe headaches, lightning headaches, seizures, altered consciousness, visual disturbances, paralysis, serious neurological symptoms.

Mild side effects

• Eosinophilia
• leukopenia
• thrombocytopenia
• diarrhea
• rash
• increased liver enzymes
• headache
• dizziness
• bronchospasm
• loose stools

This medication should be stored in a sealed container to avoid contact with air and should be kept at a cool temperature below 25 degrees Celsius. This will help maintain the medication's effectiveness and prevent degradation.

Appearance

A colorless and transparent vial injection containing a white or pale yellow powder

Package unit

1 vial x 10