Glycomin Tablets (Metformin Hydrochloride)

Adult dose

The administration dose is determined based on individual drug effects and tolerance, and should not exceed the recommended maximum dose per day. It is generally administered 2-3 times a day at 500 mg with meals. The dose increase should be gradual by 500 mg weekly, and when administering up to 2000 mg, it is usually split into two doses in the morning and evening. If this exceeds 2000 mg, it should be divided into three doses with meals, up to a total of 1.

Child dose

This can be used for children aged 10 and above and growing adolescents. The starting dose is 500 mg once a day, administered during or after meals. The dosage should be adjusted based on blood sugar measurements taken one week later.

This medication can cause severe lactic acidosis or hypoglycemia, so caution is needed. Patients with moderate to severe renal impairment, dehydration, serious infections, acute myocardial infarction, or other acute conditions that may affect renal function should not be administered this medication. Avoid use in patients with acute and unstable heart failure or those undergoing examinations using iodinated contrast agents. This medication is contraindicated in patients with hypersensitivity to this drug or to other biguanides, patients with type 1 diabetes, or those with a history of lactic acidosis or diabetic ketoacidosis. Caution is also needed in patients with severe infections, severe traumatic systemic disorders, scheduled surgeries, malnutrition, or frailty, and in those with liver dysfunction. Gastrointestinal side effects are common, especially at the beginning, which may include diarrhea, nausea, vomiting, and abdominal bloating, but usually improve over time. Lactic acidosis is rare but a very serious side effect. If symptoms such as fatigue, muscle pain, difficulty breathing, or abdominal pain occur, medical attention should be sought immediately. Patients with reduced kidney function or the elderly should undergo regular kidney function tests, and this medication should be discontinued if kidney function worsens. The risk of lactic acidosis may increase when taken with alcohol, so excessive drinking should be avoided during treatment. During situations where blood sugar control is difficult, temporary discontinuation of the medication is recommended, with the option of receiving insulin therapy as needed. Patients performing tasks that require alertness, such as operating machinery or driving, need to be aware of the risks of hypoglycemia or lactic acidosis and exercise caution. During pregnancy, this medication crosses the placenta; thus, it should not be used if there is a risk of placental dysfunction or pre-eclampsia. If blood sugar control is necessary during pregnancy, it can be used based on the physician's judgment. During breastfeeding, this medication is excreted in breast milk, so careful consideration of the need for medication treatment while nursing should be made. This medication may interact with multiple drugs, so it is crucial to inform healthcare providers of any other medicines being taken, and blood sugar and kidney function should be monitored regularly. In case of overdose, the drug can be removed through blood dialysis, so medical consultation should be sought immediately after exceeding the dose. This medication does not cause weight gain and may instead assist in weight management. Keep this medication out of the reach of children and do not transfer it to different containers.

Serious side effects

Lactic acidosis (symptoms may include lethargy, muscle pain, difficulty breathing, weakness, abdominal pain, lower body temperature, hypotension, and bradyarrhythmia), rash, severe allergic reactions, severe edema or urination abnormalities, liver abnormalities (jaundice), severe neurological symptoms (headache, seizures, confusion, vision disturbances, paralysis), respiratory problems (shortness of breath, asthma attacks, cough and fever with respiratory issues).

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain), metallic taste, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver function abnormalities, severe delayed hypoglycemia.

This medication is sensitive to air and moisture and should be stored in a tightly closed container at room temperature. It should be kept away from direct sunlight and not placed in areas that are too hot or too cold.

Appearance

White, round, film-coated tablets

Package unit

100 tablets/bottle, 500 tablets/bottle