Question 1

What are the indications and effects of Negabact Tablet (Ofloxacin)?

Accepted Answer

This drug is used to treat infections caused by various bacteria. Major indications include complex skin and soft tissue infections, acute and chronic otitis media, bacterial sinusitis, community-acquired pneumonia, acute exacerbations of chronic obstructive pulmonary disease, acute pyelonephritis, urinary tract infections, bacterial prostatitis, gastroenteritis, intrauterine infections, eye-related infections, and combination therapy for leprosy. However, it is principle that fluoroquinolone class medications, including this drug, should be used only when there are no other therapeutic options due to the risk of serious adverse reactions. Therefore, it should be used carefully under the physician's judgment for effective treatment of various bacterial infections.

Question 2

What are the dosage and administration instructions for Negabact Tablet (Ofloxacin)?

Accepted Answer

○ The usual adult dose is 300～600 mg ofloxacin per day, taken orally in 2～3 divided doses.
○ For leprosy, the dose is 400～600 mg of this medicine per day, taken orally in 2～3 divided doses. As a rule, use in combination with other antileprosy drugs.
The dose may be adjusted as appropriate according to age and symptoms.

Question 3

What are the side effects of Negabact Tablet (Ofloxacin)?

Accepted Answer

Tendinitis, tendon rupture, peripheral neuropathy, central nervous system effects, exacerbation of myasthenia gravis, anaphylactic shock, anaphylactoid reactions, rash, itching, erythema, swelling, fever, warmth, blisters, erythema, photosensitivity reactions, hematuria, acute renal failure, kidney stones, interstitial nephritis, elevated BUN, elevated serum creatinine, jaundice, liver failure, elevated AST/ALT, elevated ALP, elevated γ-GTP, increased total bilirubin, cholestatic jaundice, fulminant hepatitis, pseudomembranous colitis, abdominal pain, diarrhea, nausea, vomiting, gastric and abdominal discomfort, cirrhosis, anorexia, abdominal pain and discomfort, dyspepsia, chest pain, thirst, taste disturbances, stomatitis, glossitis, abdominal bloating, constipation, dysphagia, gastrointestinal bleeding, oral mucosal pain, bowel perforation, anemia, leukopenia, reduced hemoglobin, decreased hematocrit, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytopenic purpura, petechial and ecchymotic bleeding, prolonged prothrombin time, reversible bone marrow suppression, lymphopenia, neutropenia, increased ESR, insomnia, dizziness, headache, seizures, tremors, numbness, peripheral neuropathy, visual disturbances, auditory disturbances, hallucinations, drowsiness, nervousness, sleep disturbances, confusion, anxiety, depression, restlessness, hyperesthesia, delirium, suicidal ideation, suicide, perceptual disturbances, olfactory and balance sensory disorders, ataxia, aphasia, heaviness in the head, mucous membrane syndrome, toxic epidermal necrolysis, arthralgia, myalgia, muscle weakness, myositis, rhabdomyolysis, pharyngitis, breathing difficulty, bronchospasm, allergic pneumonia, nosebleeds, stridor, fever, cough, abnormal chest X-ray, eosinophilia, interstitial pneumonia, cerebral thrombosis, pulmonary edema, tachycardia, hypertension, hypotension, palpitations, vasodilation, circulatory collapse, QT prolongation, ventricular tachycardia, dysuria, frequent urination, urinary retention, anuria, polyuria, hematuria, storage urine, pyuria, diabetes, proteinuria, alkaline urine, vaginitis, vaginal candidiasis, increased vaginal discharge, vulvar itching in women, irregular menstruation, uterine cramps, rash in female genitalia, pain, irritation, burning sensation, hypoglycemia, limb pain, malaise, fever, aortic aneurysm, aortic dissection, heart valve regurgitation, heart valve insufficiency

Question 4

What precautions should be taken when using Negabact Tablet (Ofloxacin)?

Accepted Answer

This drug may cause issues with tendons, such as tendonitis or tendon rupture, and should be discontinued immediately if such symptoms appear.

Peripheral neuropathy may cause unusual sensations or numbness in the hands and feet, so if these symptoms occur, the drug should be stopped and the physician consulted.

It may affect the central nervous system, leading to symptoms such as dizziness, headaches, or seizures, so caution is necessary.

Patients with myasthenia gravis should not use this medication as it may worsen symptoms.

Elderly patients or those with impaired kidney function require dose adjustments and careful administration due to slower drug excretion and higher risk of side effects.

Pregnant women or those who may become pregnant, nursing mothers, and adolescents under 18 years of age should not take this medication.

Care should be taken to avoid strong sunlight or artificial ultraviolet exposure while taking this medication, and if skin rashes or itching occur, the medication should be stopped immediately.

There may be interactions with other medications, especially those that affect blood coagulation or diabetes, so consultation with a physician is necessary, and blood sugar and bleeding risk should be closely monitored.

If symptoms such as hypotension, difficulty breathing, or severe allergic reactions occur during treatment, inform medical staff immediately.

Adequate hydration is necessary while taking this medication, and if neurological adverse reactions such as dizziness occur, driving or operating dangerous machinery should be avoided.

The safety of this drug in children has not been established, so it should not be used in this population, and regular blood and liver function tests are advisable.

When storing the medication, keep it out of reach of children and do not transfer it to other containers.

Negabact Tablet (Ofloxacin)

Summary

Ingredients

Efficacy & effects

Dosage and Administration

Adult dosage

Precautions

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Appearance

Package unit

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