Innoen 8.5% Hura Basol Injection

Adult administration

Adults: Administer 1 to 1.5 g of total amino acids per kg of body weight per day as the maximum dose via intravenous drip. Infusion rate: A concentration of approximately 10 g of total amino acids over 60 minutes is preferred, and it is recommended to administer 25-30 drops per minute.

Child administration

For children, the dosage and infusion rate should be adjusted appropriately.

This medication must be used strictly according to a doctor's instructions. It should not be used in patients with severe renal dysfunction or high nitrogen levels in the blood. It should not be administered to patients with liver dysfunction or those with amino acid metabolism issues. Administration is prohibited in patients with metabolic disorders that impair nitrogen utilization. Patients with severe heart failure or pulmonary edema should not use this medication. It should not be administered to patients with very low or absent urine output. If sodium or chloride ions are included, it should not be given to patients with hypernatremia, hyperchloremia, or alkalosis. If magnesium ions are present, it should not be used in patients with heart block or severe myasthenia gravis. Patients with a history of myocardial infarction should not receive this medication. Caution should be exercised in patients with severe acidosis or congestive heart failure. Patients with edema due to sodium retention or those with hyperkalemia, or patients with reduced liver or kidney function should use this medication cautiously. Allergic reactions like rash may occur, so if such symptoms appear, administration should be stopped immediately. Gastrointestinal symptoms such as nausea or vomiting may occur. Cardiovascular symptoms such as chest discomfort, palpitations, rapid heartbeat, or elevated blood pressure may occur. Rapid administration of large quantities may lead to acidosis. Chills, fever, headache, shortness of breath, respiratory failure, shock, bronchospasm, or urinary tract spasms may occasionally occur. Metabolic complications such as acidosis, hypophosphatemia, alkalosis, hyperglycemia, diabetes, dehydration, hypoglycemia, elevated liver enzymes, vitamin deficiencies or overdoses, electrolyte imbalances, and hyperammonemia in children may occur. Patients with renal failure may experience elevated blood urea nitrogen levels. Patients with liver failure may show serum amino acid imbalance, metabolic alkalosis, systemic nitrogen retention, hyperammonemia, and altered consciousness. Care should be taken regarding electrolyte balance during large dosing or when used with electrolyte solutions. Caution should be exercised as metabolic alkalosis may occur with overdose. Patients with kidney disease, lung disease, or severe heart disease should be administered slowly to avoid fluid overload side effects. Blood sugar levels must be frequently monitored when administering to diabetic patients. This medication is hypertonic, so it may cause venous irritation during intravenous injection. During administration, various clinical tests such as blood sugar, liver function, kidney function, and electrolytes should be frequently performed to monitor for abnormalities. Amino acid mixtures can exacerbate folic acid deficiency, so daily folic acid supplementation is necessary. To enhance the use of amino acids in protein synthesis, appropriate non-protein energy sources should be administered alongside, such as concentrated glucose solution. When used with glucose solution, hyperglycemia or diabetes, or hypertonic syndrome may occur, so blood and urine glucose levels should be monitored. Caution is required for potential interactions when combined with other medications. Safety has not been established during pregnancy; it should only be used if the therapeutic benefit outweighs the risks. In children, the dosage should be reduced due to immature liver function, and blood ammonia levels should be frequently measured. Elderly patients should have their infusion rates slowed and dosages adjusted due to decreased body function. When administering, attention should be paid to electrolyte balance according to whether the solution contains electrolytes, and the infusion rate should be slow. In cold weather, the solution should be warmed to body temperature before use. High standards of sterility must be maintained during the administration process to minimize infection risk. The solution should not be used if it is discolored or has leaked, and packaging should be kept intact until opened for storage. Remaining solution should be used within 24 hours, and if crystals form, it should be heated and then cooled to body temperature before use.

Serious side effects

• Severe allergic reactions such as hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, and paleness may occur.
• Severe skin adverse reactions such as high fever, along with severe rashes, blisters, skin peeling, and mucous membrane pain in the mouth/eyes may appear.
• Respiratory issues such as shortness of breath or difficulty breathing, asthma attacks, and coughing with fever may occur.

Mild side effects

• Allergic reactions such as rashes may rarely occur.
• Gastrointestinal symptoms such as nausea and vomiting may occasionally occur.
• Cardiovascular symptoms such as chest discomfort, palpitations, rapid heartbeat, or elevated blood pressure may occasionally occur.
• Rapid large volume administration may lead to acidosis.
• Chills, fever, headache, and urinary tract spasms may occasionally occur.
• Metabolic acidosis, hypophosphatemia, alkalosis, and hyperglycemia, diabetes.

This medication should be stored in an airtight container to prevent air or moisture ingress, and the storage temperature should be room temperature, i.e., maintaining a general indoor temperature that is neither too hot nor too cold. Storing it this way will help maintain the drug's effectiveness and prevent deterioration.

Appearance

A colorless or pale yellow transparent injectable solution filled in a colorless transparent plastic container.

Package unit

250, 500 milliliters