Innoen Hartmann Solution

Adult administration

Typically, 500–1,000 mL is administered via slow intravenous infusion for adults. The infusion rate should be 300–500 mL per hour (75–120 drops per minute). The dosage and rate should be appropriately adjusted according to age, weight, and symptoms.

This medication may cause precipitation when used concurrently with intravenous calcium-containing preparations and ceftriaxone; therefore, both medications should not be administered together using the same infusion equipment. If the same infusion line must be used, it should be thoroughly cleaned before and after use. Allergic reactions may occur with the use of this medication; if any signs of hypersensitivity appear, immediately discontinue administration and seek necessary treatment. This medication contains potassium, which may pose a risk of increasing serum potassium levels; therefore, patients with impaired kidney function or heart disease, as well as those taking medications that increase the risk of hyperkalemia, should exercise caution. Such patients should regularly monitor their serum potassium levels. This medication may also increase sodium and chloride levels, potentially leading to electrolyte imbalance. Patients with conditions such as hypertension, heart failure, or liver disease should consult with a physician before use and frequently check their sodium, chloride levels, and kidney function. Moreover, this medication can cause hyponatremia; therefore, particular caution should be taken with children, the elderly, postoperative patients, patients with mental disorders, and those taking medications that increase the risk of hyponatremia. Hyponatremia can lead to severe neurological symptoms such as headaches, vomiting, and seizures, so frequent monitoring through blood tests is recommended. Patients with high calcium levels or a history of calcium kidney stones should avoid using this medication, and caution is needed in cases where there is a risk of fluid overload. Long-term use of this medication requires continuous monitoring of fluid balance and electrolyte status. Lactic acidosis, fluid overload, hypernatremia patients, newborns (especially when combined with ceftriaxone), and those allergic to this medication or its components should not be administered this medication. Patients with severely impaired kidney or liver function, heart failure, or hypertonic dehydration should use this medication cautiously and those with hyponatremia should also exercise caution. Rapid administration of this medication can cause cerebral edema, pulmonary edema, and peripheral edema; therefore, it should be administered slowly. Adverse reactions related to the immune system or electrolyte imbalances, as well as cardiac abnormalities, have been reported, so immediate consultation with a healthcare professional is required if any abnormal symptoms arise. During administration, blood glucose, serum electrolytes, and fluid status should be regularly checked to ensure there are no abnormalities. This medication can interact with various drugs, so caution is needed when used with other antibiotics, vitamins, pain relievers, etc. Especially when combined with drugs that may induce hyperkalemia, serum potassium levels should be frequently monitored. When used with lithium or digoxin, changes in serum concentration should be monitored, and dosing or infusion rate should be adjusted as necessary. The safety of this medication during pregnancy has not been fully established, so it should be used cautiously under the guidance of a physician. In children and the elderly, serum electrolyte levels and fluid status should be monitored more carefully during administration. This medication should not be mixed with formulations containing phosphates or carbonates, and prior to administration, the patient’s skin and equipment should be thoroughly disinfected for infection prevention. During administration, it should be warmed to body temperature and used immediately after opening, and any leftover medication should not be reused. Lastly, store this medication at room temperature and administer it slowly for safety.

Serious side effects

• Anaphylaxis
• systemic urticaria and erythema
• rash
• urticaria
• dyspnea
• cerebral edema
• pulmonary edema
• peripheral edema
• cardiac arrest

Mild side effects

• Vomiting
• hypertension
• tachycardia
• chills
• fever
• hyperkalemia
• hyponatremia
• hypernatremia
• hyperchloremic acidosis
• electrolyte imbalance

This medication should be stored in a sealed container to prevent air or humidity infiltration, kept away from direct sunlight, and at room temperature. This storage can help maintain the effectiveness of the medication for a longer period.

Appearance

A clear and colorless intravenous injection solution filled in a clear plastic bottle sealed with a semi-transparent high-density polyethylene.

Package unit

500, 1000 milliliters