Vancomycin Injection (Vancomycin Hydrochloride)

Adult dosage

(Capsules) As Vancomycin, 500 mg (potency) per day divided into doses for oral administration for 7–10 days. In severe cases, 2 g (potency) can be administered in divided doses of 3–4 times a day, not exceeding a total daily dose of 2 g. (Injection) 500 mg (potency) intravenously every 6 hours or 1 g (potency) every 12 hours by drip infusion. (Oral administration) 500–2000 mg per day in 3–4 doses.

Children's dosage

(Capsules) 40 mg (potency) per kg of body weight per day, divided into 3–4 doses for 7–10 days, not exceeding a total daily dose of 2 g. Adjust according to age and symptoms. (Injection

This drug should not be used in patients with a history of allergic reactions to this medication or its ingredients. Caution is needed in patients who had allergic reactions to peptide antibiotics or aminoglycoside antibiotics before using this medication. Patients with hearing impairment or previous hearing issues should use this drug cautiously as it may worsen hearing loss. Patients with poor kidney function should be closely monitored while using this medication as it may accumulate in the body and cause side effects. Elderly patients may have decreased kidney function, possibly delaying drug excretion, requiring dosage adjustments. This drug can rarely cause serious allergic reactions such as hypotension, dizziness, rash, and difficulty breathing; if any abnormal symptoms occur, administration should be stopped immediately and appropriate treatment should be sought. Prolonged or excessive use may lead to the development of resistant bacteria, so the duration and dosage prescribed by the doctor should be strictly adhered to. Regular blood tests and kidney function tests should be conducted during the administration of this medication, and hearing tests may also be necessary. Women who are pregnant or breastfeeding should consult a doctor before using this medication as it may affect the fetus or baby. The risk of side effects may increase when this drug is used in conjunction with other nephrotoxic or neurotoxic medications, so caution is warranted during concomitant use. Overdosage may lead to severe side effects such as renal dysfunction or hearing loss; therefore, patients must adhere to the prescribed dosage and inform healthcare professionals immediately if overdose is suspected.

Serious side effects

• Hives, severe swelling (edema), hypotension, wheezing, dizziness, hypotension → severe allergic reactions.
• Severe rash with fever, blisters, skin peeling, mucosal pain in the mouth/eyes → severe cutaneous adverse reactions.
• Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS, AGEP, vasculitis, linear IgA bullous dermatosis (LABD) → severe cutaneous adverse reactions.
• Shortness of breath, wheezing, hypotension, chest tightness →

Mild side effects

• Oral dysesthesia
• dizziness
• constipation
• tinnitus
• sweating
• drug-induced fever
• flushing
• nausea
• loss of appetite
• chills

This medication should be stored in a sealed container to prevent air ingress and kept at a temperature between 1°C and 30°C. Proper storage helps maintain the efficacy of the drug and prevent degradation.

Appearance

A white to light yellowish-brown freeze-dried powder contained in a colorless transparent vial for injection.

Package unit

10 vials