Hemotrate B1

Adult administration

Depending on the patient's condition and the type of artificial kidney used, an appropriate basic solution for artificial kidney dialysis should be selected and used with this solution and purified water after dilution.

This medication should be used with caution in patients with severe liver dysfunction or severe diabetes who have problems with acetic acid metabolism. If acetic acid is not properly metabolized, it can suppress heart function or dilate blood vessels, leading to symptoms of low blood pressure. Additionally, patients taking digitalis preparations should be carefully administered as low potassium levels may increase the risk of digitalis toxicity. Caution is required for patients with very high serum calcium and phosphorus levels before dialysis, as this medication can induce metastatic calcification. Patients with insufficient calorie intake, dietary restrictions due to diabetes, or those using hypoglycemic agents should also be cautious as symptoms of hypoglycemia may occur. When using this medication, regular blood tests are necessary to monitor for complications related to bones such as hypoglycemia, hypercalcemia, osteoporosis, osteomalacia, and fibrous osteitis. Symptoms of dialysis disequilibrium syndrome such as headache, nausea, vomiting, convulsions, or altered consciousness may occur during or after dialysis, and appropriate action should be taken immediately if symptoms appear. Effects on the circulatory system may lead to low blood pressure or shock symptoms; therefore, if these symptoms occur, dialysis should be stopped or adjusted, and necessary treatment should be provided. Pregnant women or women who could become pregnant should only use this medication when the benefits of treatment outweigh the risks, as its safety has not been established. Safety in pediatric patients has not been established, so caution is required when administering to children. For elderly patients, there is a risk of bone-related complications with prolonged use, so regular clinical examinations and, if necessary, administration of active vitamin D3 preparations are recommended. This medication must be used with attentiveness to the quality of the diluent for dialysis, and care should be taken for potential damage to the dialysis membrane or a tendency for postoperative bleeding. When compounding, do not use the electrolyte solutions for artificial kidney dialysis or sodium bicarbonate solutions alone; they should be exactly prepared with the specified diluents. Before using, verify that the electrolyte concentration, osmotic pressure, and pH of the dialysis solution are appropriate. The compounded dialysis solution should be used immediately, and it should not be used if left at 38 degrees Celsius for more than 2 hours, as insoluble particulates may form. Additionally, this medication should not be used for injections or peritoneal perfusion, and it is important to adjust the temperature to that of body temperature when used.

Serious side effects

• Altered consciousness
• disturbances in consciousness
• convulsions

Mild side effects

Hypoglycemia, hypercalcemia, osteoporosis, osteomalacia, fibrous osteitis, metastatic calcification, symptoms of dialysis disequilibrium syndrome (headache, nausea, vomiting, convulsions, malaise, fatigue), low blood pressure, shock symptoms, hypertension, headache, palpitations, elevated blood pressure, altered consciousness, loss of limb sensation, generalized malaise, chest discomfort, rapid drop in blood pressure, altered consciousness

This medication should be stored at room temperature and kept in a sealed container to prevent air and moisture from entering. This helps maintain the effectiveness of the medication for a longer duration.

Appearance

A colorless and transparent solution filled in a white translucent plastic container.

Package unit

5.5L, 10L