Gadin Injection (Ranitidine Hydrochloride)

Adult dosage

As ranitidine, administer 50mg intravenously or intramuscularly 3-4 times a day. For intravenous administration, dilute this medication 50mg in 20ml of normal saline or dextrose solution and administer slowly for at least 2 minutes or mix it in infusion and deliver it at a rate of 25mg/hr over 2 hours. In the case of pre-anesthesia dosing, administer 50mg intramuscularly or slowly intravenously over 1 minute, 45-60 minutes before anesthetic induction.

This medication should not be administered to patients with hypersensitivity to its components. Patients with impaired renal function may experience prolonged retention of this medication in the body, which can increase the risk of side effects; therefore, use caution by reducing the dosage or extending the administration interval. Caution is also needed for patients with impaired liver function, those with a history of drug hypersensitivity, and elderly patients. Patients with a rare history of acute porphyria should not use this medication. This medication may rarely cause serious allergic reactions, Blood abnormalities, liver dysfunction, cardiac problems, gastrointestinal symptoms, neurological anomalies, skin rashes, etc. If any abnormal symptoms occur, discontinue administration immediately and inform a healthcare provider. During treatment, regular blood tests, liver function tests, and renal function tests should be performed to monitor for abnormalities. Elderly patients or those with chronic pulmonary diseases, diabetes, or weakened immune systems should be cautious as they may have an increased risk of pneumonia. If high doses of this medication are administered intravenously for more than 5 days, liver enzyme levels may rise, and daily liver function tests are recommended. If oral administration is possible, it is advisable to switch to an oral form; this medication should only be used when oral administration is difficult. This medication may interact with other drugs, necessitating dosage adjustment or discontinuation of concomitant medications; therefore, it's essential to inform healthcare providers of any medications currently being taken. Pregnant women or those who might become pregnant and nursing mothers should only use this medication cautiously if necessary. The safety of this medication in pediatric patients has not been adequately established, so caution is advised for use. This medication may affect the results of certain clinical tests; thus, it is important to inform healthcare professionals during testing. In the event of overdose, emergency measures such as inducing vomiting or gastric lavage may be necessary, and in severe cases, blood dialysis may be required. Administration via injection may cause pain or induration at the injection site, and in patients at risk of abnormal heart rate, the infusion should be done slowly. This medication can mask symptoms of stomach cancer; therefore, gastric ulcer patients or those experiencing new or worsening dyspeptic symptoms in middle age should have malignancy ruled out before administration. Regular eye examinations are recommended to check eye health during long-term administration.

Serious side effects

• Urticaria
• angioedema
• fever
• bronchospasm
• hypotension
• chest pain
• vascular edema
• anaphylactic shock
• jaundice
• hepatitis

Mild side effects

Granulocytopenia, increased serum creatinine, leukopenia, thrombocytopenia, bone marrow suppression, aplastic anemia, hypoplastic anemia, agranulocytosis, pancytopenia, autoimmune hemolytic anemia, eosinophilia, transient and reversible liver dysfunction (elevated AST, ALT, γ-GTP, ALP levels), bradycardia, heart block, tachycardia, vasculitis, cardiac arrest, constipation, nausea, vomiting, abdominal bloating, abdominal pain, loss of appetite,

This medication should be stored in a sealed container to protect it from air and light. It is advisable to keep it at room temperature and avoid direct sunlight. Proper storage helps maintain the medication's efficacy.

Appearance

An ampoule containing a light yellow transparent solution

Package unit

50 ampoules