Pajeロン Injection 500 milligrams (Cefazedone Sodium)

Adult administration

For the treatment of infections caused by gram-positive bacteria as cefazolin sodium, administer 1-2g (potency) intravenously in 2-3 doses per day. For infections caused by gram-negative bacteria, administer 3-4g (potency) intravenously in 2-3 doses per day. In life-threatening infections and infections by moderately susceptible bacteria, the dose can be increased up to 6g (potency) per day. Dissolve 1g (potency) in 5mL of sterile water for injection and administer slowly over 2-3 minutes.

This drug should not be used in patients with hypersensitivity to cephalosporin antibiotics. It is also unsafe for use in premature and newborn infants. It should be used with caution in pregnant women during the first trimester, and patients with kidney or liver dysfunction must be monitored closely. Patients with hemophilia or thrombocytopenia should be careful due to the risk of bleeding. Patients with gastrointestinal ulcers also need caution when using this drug. Patients who cannot take medication orally, those receiving parenteral nutrition, the elderly, and patients with poor overall health should be closely observed for symptoms of vitamin K deficiency. Using this drug may temporarily cause mild hypersensitivity reactions such as headaches, dizziness, and nausea. Rarely, serious allergic reactions such as skin rashes, fever, and anaphylaxis may occur; if symptoms appear, administration should be stopped immediately and appropriate treatment should be sought. Liver function test values may temporarily rise, so liver condition should be monitored. Temporary leukopenia may occur, necessitating blood tests. Severe colitis symptoms, such as pseudomembranous colitis, are rare but may occur, and if abdominal pain or diarrhea worsens, administration should be stopped immediately. Nausea, vomiting, and loss of appetite can also occur occasionally. If respiratory symptoms such as fever, cough, or difficulty breathing occur, they may indicate interstitial pneumonia or PIE syndrome, necessitating cessation of administration and appropriate treatment. Phenomena such as oral thrush or candidiasis may rarely occur due to microbial imbalance. Bleeding tendencies or vitamin B deficiency symptoms due to vitamin K deficiency may also appear, so caution is needed. This drug should be administered only after susceptibility testing to prevent the development of resistant strains, and used only for the minimum necessary duration. It is advisable to conduct an interview and skin tests to assess for allergic reactions before administration. Emergency preparedness should be in place for acute allergic reactions, and the patient's condition should be sufficiently monitored after administration. First-generation cephalosporin antibiotics are increasing in resistance, so sensitivity test results should guide use. Caution is needed when used in conjunction with aminoglycoside antibiotics, as it may affect kidney function. Combining with polymyxin B, colistin, and high-dose diuretics can also increase the risk of kidney damage, so care is warranted. When used with high-dose oral anticoagulants, careful monitoring of blood coagulation status is required. When breastfeeding, this drug may pass into breast milk in small amounts, so it should be given with caution. Finally, this drug should not be mixed and injected in the same syringe with aminoglycoside antibiotics.

Serious side effects

• Anaphylaxis
• skin rash accompanied by high fever
• difficulty breathing
• severe colitis
• interstitial pneumonia
• PIE syndrome.

Mild side effects

• Transient mild headache
• dizziness
• nausea
• skin rash
• fever
• abdominal pain
• frequent diarrhea
• vomiting
• loss of appetite
• stomatitis

This drug should be stored in a sealed container to protect it from air and moisture. Additionally, it is recommended to keep the medication at room temperature, neither too cold nor too hot, ideally between 1 degree Celsius and 30 degrees Celsius.

Appearance

A colorless, transparent vial filled with a white to light yellow powder

Package unit

10 vials (500mg/vial x 10)