Medication info
Ephexin Tablet 100 mg (Ofloxacin)

Ephexin Tablet 100 mg (Ofloxacin)

Prescription medicationTabletOral
Ingredient · strength
Ofloxacin›100mg / 1 tablet
Manufacturer / importer
Il Dong Pharmaceutical Co., Ltd.
Appearance
White round film-coated tablets
Packaging
30 tablets/bottle, 300 tablets/bottle
Approval status
Active

MFDS item code 199100426 · Notified 1991.03.27 · Insurance code 642901320

Summary

Main use
Treatment of bacterial infections (e.g., urinary tract, respiratory, and skin infections); adjunctive treatment of leprosy
Who takes it
Adults
Adult dose
○ Usually, adults take 300~600 mg of ofloxacin per day in 2~3 divided doses. ○ For leprosy, take 400~600 mg of this medicine per day in 2~3 divided doses. In principle, it should be used in combination with other antileprosy drugs. The dose may be adjusted appropriately according to age and symptoms.

Ingredients

Manufacturer
Il Dong Pharmaceutical Co., Ltd.

Efficacy & effects

Treatment of bacterial infections (e.g., urinary tract, respiratory, and skin infections); adjunctive treatment of leprosy

  • Complicated skin and soft tissue infections
  • acute otitis media
  • chronic suppurative otitis media
  • chronic cholesteatoma otitis media
  • acute and chronic bacterial sinusitis
  • community-acquired pneumonia
  • chronic bronchitis
  • acute exacerbation of chronic obstructive pulmonary disease
  • acute pyelonephritis
  • simple acute cystitis
  • bacterial prostatitis
  • epididymitis
View approved original text

This medication is used to treat various bacterial infections. The main indications include complicated skin and soft tissue infections, acute and chronic otitis media, bacterial sinusitis, community-acquired pneumonia, and acute exacerbation of chronic obstructive pulmonary disease. It is also effective for urinary tract infections such as acute pyelonephritis, cystitis, prostatitis, and urethritis. Additionally, it is used in the combination therapy for bacterial enteritis, endometritis, infections around the eyes, and leprosy. However, this medication is recommended for use only when there are no other treatment options available due to the risk of serious adverse reactions. Overall, it is safely and effectively used to treat a variety of bacterial infections.

How to take

Adult dose

○ Usually, adults take 300~600 mg of ofloxacin per day in 2~3 divided doses. ○ For leprosy, take 400~600 mg of this medicine per day in 2~3 divided doses. In principle, it should be used in combination with other antileprosy drugs. The dose may be adjusted appropriately according to age and symptoms.

Precautions

This medication is a specific type of antibiotic that can cause serious side effects such as tendonitis or tendon rupture. If there is pain or inflammation in a tendon, the use of this medication must be stopped immediately, and rest should be taken while avoiding strenuous exercise. It should not be used in patients with myasthenia gravis due to the risk of worsening symptoms. Furthermore, this medication should not be administered to children, growing adolescents, or women who are pregnant or breastfeeding. Caution should be exercised in patients with significantly impaired kidney or liver function, the elderly, or those with a history of mental illness. This medication can cause serious allergic reactions or various side effects involving the liver, kidneys, gastrointestinal tract, skin, and nervous system, so if any abnormal symptoms occur, immediate consultation with a physician is necessary. Additionally, excessive exposure to sunlight while using this medication may lead to skin reactions, so it is advisable to avoid direct sunlight. Diabetic patients who require blood sugar control should carefully monitor blood sugar changes while taking this medication. This medication may interact with other drugs; therefore, if any other medications are being taken, it is crucial to inform the healthcare provider. Women who are pregnant or may become pregnant should not use this medication, and breastfeeding mothers should discontinue breastfeeding. In case of overdose, immediate visit to a healthcare facility for appropriate treatment is required, as this medication may not be completely removed by hemodialysis. When used as an injectable, intravenous injections should be administered slowly, and it should not be mixed with other medications. Finally, this medication should be kept out of the reach of children and should not be transferred to other containers.

Side effects

  • Tendinitis
  • tendon rupture
  • peripheral neuropathy
  • central nervous system effects
  • exacerbation of myasthenia gravis
  • anaphylactic shock
  • anaphylactic reaction
  • rash
  • itching
  • erythema
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  • edema
  • fever
  • warmth
  • photosensitivity reaction
  • hematuria
  • acute renal failure
  • kidney stones
  • interstitial nephritis
  • elevated BUN
  • elevated serum creatinine
  • jaundice
  • liver failure
  • elevated AST/ALT
  • elevated ALP
  • elevated γ-GTP
  • elevated total bilirubin
  • cholestatic jaundice
  • membranous colitis
  • colitis with bloody stools
  • nausea
  • vomiting
  • gastric and abdominal discomfort
  • diarrhea
  • cirrhosis
  • loss of appetite
  • abdominal pain
  • dyspepsia
  • chest pain
  • thirst
  • taste disturbance
  • stomatitis
  • glossitis
  • abdominal distension
  • constipation
  • dysphagia
  • gastrointestinal bleeding
  • oral mucosal pain
  • intestinal perforation
  • anemia
  • leukopenia
  • decreased hemoglobin
  • decreased hematocrit
  • thrombocytopenia
  • eosinophilia
  • agranulocytosis
  • thrombotic thrombocytopenic purpura
  • petechiae and purpura
  • prolonged prothrombin time
  • reversible bone marrow suppression
  • lymphopenia
  • neutropenia
  • increased ESR
  • insomnia
  • dizziness
  • headache
  • seizures
  • tremors
  • paresthesia
  • peripheral nerve disorders
  • visual disturbances
  • auditory disturbances
  • hallucinations
  • drowsiness
  • irritability
  • sleep disturbances
  • somnolence
  • anxiety
  • depression
  • restlessness
  • euphoria
  • confusion
  • seizures
  • nightmares
  • paranoia
  • disorientation
  • attention deficit
  • memory impairment
  • delirium
  • suicidal thoughts
  • suicide
  • perceptual disturbances
  • olfactory and equilibrium disorders
  • ataxia
  • aphasia
  • heaviness in the head
  • Stevens-Johnson syndrome
  • toxic epidermal necrolysis
  • arthralgia
  • myalgia
  • muscle weakness
  • myositis
  • malaise
  • elevated CPK
  • elevated myoglobin in blood and urine
  • rhabdomyolysis
  • pharyngitis
  • respiratory distress
  • bronchospasm
  • allergic pneumonia
  • nosebleed
  • stridor
  • fever
  • cough
  • abnormal chest X-ray
  • eosinophilia
  • interstitial pneumonia
  • cerebral thrombosis
  • pulmonary edema
  • tachycardia
  • hypertension
  • hypotension
  • palpitations
  • vasodilation
  • circulatory collapse
  • prolonged QT interval
  • ventricular tachycardia
  • dysuria
  • polyuria
  • urinary retention
  • anuria
  • polyuria
  • hematuria
  • storage of urine
  • pyuria
  • diabetes
  • proteinuria
  • alkaline urine
  • vaginitis
  • vaginal candidiasis
  • increased vaginal discharge
  • vulvar itching in women
  • menstrual irregularities
  • uterine cramps
  • genital rash in women
  • pain
  • irritation
  • burning sensation
  • hypoglycemic symptoms
  • limb pain
  • fatigue
  • fever

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly sealed container to prevent air exposure and is best kept at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness for a longer period.

Appearance and packaging

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.